慢性淋巴细胞白血病患者并发非甲状腺疾病综合征的预后
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国家自然科学基金(81370657)


Prognosis of chronic lymphocytic leukemia patients with non-thyroidal illness syndrome
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    摘要:

    目的:探讨非甲状腺疾病综合征(non-thyroidal illness syndrome,NTIS)在慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)患者中的发生率-临床特征及预后-方法:检测78例CLL患者的甲状腺功能,结合临床资料分析NTIS发病的可能诱因-临床表现及发病后的总生存期 (overall survival,OS)-结果:78例CLL患者中14例并发NTIS,NTIS与疾病晚期(Binet C期)(P=0.021)-血红蛋白减少(P < 0.001)-血小板计数减低(P=0.012)-低白蛋白血症(P=0.018)和高C反应蛋白水平(P=0.007)显著相关-生存分析显示,伴NTIS患者的中位OS明显短于无NTIS者(P < 0.001)-结论:部分CLL患者伴发NTIS,推测其原因可能与CLL患者全身炎症反应或营养状态恶化有关,伴NTIS提示预后不良-

    Abstract:

    Objective:To assess the prevalence,clinical characteristics and prognostic accuracy of non-thyroidal illness syndrome(NTIS)in patients with chronic lymphocytic leukemia (CLL). Methods:Thyroid function and clinical data were examined in 78 patients with CLL to identify potential predisposing factors,evaluate clinical features and overall survival(OS). Results:Among 78 CLL patients,14 patients were diagnosed as NTIS. NTIS of CLL was significantly correlated with advanced Binet stage (Binet C)(P=0.021),decreased hemoglobin(P < 0.001),platelet count(P=0.012)and albumin(P=0.018),and increased C reaction protein(CRP)(P=0.007). The patients with NTIS had shorter median OS than patients without NTIS (P < 0.001). Conclusion:NTIS was present in some CLL patients,and that may be related with systemic inflammation and nutritional decline of patients. CLL patients with NTIS have a poor prognosis.

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陈睿泽,夏 奕,吴佳竹,梁金花,王 莉,范 磊,李建勇,徐 卫.慢性淋巴细胞白血病患者并发非甲状腺疾病综合征的预后[J].南京医科大学学报(自然科学版),2016,(6):730-734

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  • 收稿日期:2015-12-01
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  • 在线发布日期: 2016-06-15
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