血清视黄醇结合蛋白在危重患者营养支持效果评价中的意义
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Significance of serum retinol binding protein in nutrition support evaluation for critical patients
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    目的:探讨血清视黄醇结合蛋白(retinol binding protein,RBP)在危重患者营养支持效果评价中的意义-方法:2013年9月—2014年4月南京医科大学第一附属医院重症医学科68例ICU住院患者作为实验组,计算入院时及入院营养支持7 d后APACHE Ⅱ评分,测定入院时及行营养支持7 d后血清RBP-白蛋白-转铁蛋白及血红蛋白水平;65例门诊体检者为对照组-结果:实验组入院时血清RBP-白蛋白-转铁蛋白及血红蛋白水平明显低于对照组(P < 0.001),经过7 d营养支持,血清RBP水平较入院时显著升高(P < 0.001),转铁蛋白及血红蛋白较入院时升高(P < 0.05),而白蛋白水平较入院时有所下降,但差异无统计学意义(P > 0.05),血清RBP水平与APACHE Ⅱ评分呈显著负相关(P < 0.01)-结论:血清RBP能够及时-准确地反映危重患者营养支持的效果,同时可以动态评估病情变化-

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    Objective:To discuss the significance of serum retinol binding protein in nutrition support evaluation for critical patients. Methods:A total of 68 patients in ICU of the First Affiliated Hospital of NJMU between Sep. 2013 and Apr. 2014 were chosen. The levels of serum RBP,albumin,transferrin and hemoglobin were detected and APACHE Ⅱ scores were calculated at admission and after 7-day nutrition support. Sixty-five outpatient underwent physical examination were included in the control group. Results:Levels of serum RBP,albumin,transferrin and hemoglobin in the experimental group were significantly lower at admission than those in the control group (P < 0.001),while there was a remarkable increase in serum RBP level after 7-day nutrition support than on admission (P < 0.001);transferrin and hemoglobin concentrations were increased mildly (P < 0.05) and there was no significant change in albumin (P > 0.05). Serum RBP levels were negatively related with APACHE Ⅱscores. Conclusion:Serum RBP could timely and as well as accurately reflect the effect of nutrition support as well as dynamic change of illness for critical patients.

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韩 涛,阙 军,曹 权.血清视黄醇结合蛋白在危重患者营养支持效果评价中的意义[J].南京医科大学学报(自然科学版),2016,(6):750-752

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  • 收稿日期:2015-10-16
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  • 在线发布日期: 2016-06-15
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