Research progress of miRNA signaling pathway in regulatory T cells （Treg）
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摘要:
CD4+CD25+FoxP3+调节性T细胞（regulatory T cell， Treg）在维持机体免疫平衡中起着不可或缺的作用。在目前的医学临床研究中，适量输注Treg细胞被证明是一种治疗移植物抗宿主疾病（graft-versus-host disease， GVHD）的有效方式。因此，如何通过适当的方法增强Treg细胞的免疫抑制功能、增殖能力及体内存活时间成为基础和临床免疫学研究学者们非常关注的一个课题。microRNAs （miRNAs）是一类能够对mRNA进行负调节从而抑制靶蛋白表达的非编码RNA，目前有数个miRNA被证明能够直接或间接影响Treg细胞功能。在此我们对这些miRNA信号通路与Treg细胞之间的关系作一综述，为将来的基础和临床研究提供新的思路。
Abstract:
CD4+CD25+FoxP3+ regulatory T cell （Treg） plays an indispensable role in the maintenance of immune balance. In current clinical trials， Treg infusion has been proved to be an effective way to treat graft-versus-host disease （GVHD）. Therefore， how to improve Treg function， proliferation and survival by appropriate means is very important for basic and clinical immunology researchers. MicroRNAs （miRNAs） are a class of non-coding RNAs that can negatively regulate mRNA and inhibit the expression of target proteins. Several miRNAs have been shown to influence Treg function directly or indirectly. Here， we provide an overview of the relationships between these discovered miRNA signaling pathways and Treg cells， which might give a new insight into future basic and clinical studies.
