Objective:To investigate the correlation between 6p21.1 rs2494938 and 7p15.3 rs2285947 and risk of cervical cancer. Methods:A total of 571 cervical cancer patients and 657 cancer-free controls were recruited in the study. The genotypes of 6p21.1 rs2494938 and 7p15.3 rs2285947 were detected by TaqMan MGB probe method. The correlation between the SNPs and the susceptibility to cervical cancer was evaluated using unconditional logistic regression analysis,and the relative risk of odds ratio(OR)and 95% confidence interval(CI) were calculated. Results:There was no significant association between the frequencies of GA or AA among the case and control groups at SNP rs2494938 (P=0.848). There was significant association between the frequencies of GA or AA among the case and control groups at SNP rs2285947,(P=0.028),and significant reduction was found in the risk of cervical cancer between all mutation genotype(GA + AA)and wild type genotype GG(OR=0.77,95%CI:0.62~0.97,P=0.025). Conclusion:There was no significant association between the rs2494938 pleiotropy and cervical cancer susceptibility,and there was significant association between the rs2285947 pleiotropy and cervical cancer susceptibility.