Objective: To investigate the Protective effect of Zhenwu Decoction on heart and renal tissues of type 2 CRS model rats. Methods: We built type 2 CRS model rats by combining ligation of left descending coronary artery and subtotal nephrectomy. Thirty-two rats were randomly divided into low, middle, high dose treatment and control groups. Treatment groups were given different concentration but same volume decoction for lavage and control group was treated with same amount of distilled water. Serum index, echocardiogram and immunohistochemical results were compared. Results: Compared with the control group, the high dose treatment group has reduced serum Cr and BUN level but higher excretion of urine indoxyl-sulfate (P<0.05). Serum Cr and BUN levels were lower in middle dose treatment group than the control group (P<0.05). All treatment groups had a higher amount of Lvpw(systolic),CO and SV than the control group. Addition,the high dose treatment group has increased diameter and volume of left ventricle. Masson staining, Collagen I and TGF-β immunofluorescensce results all demonstrate less fibrosis in heart and kidney tissues of the treatment groups than the control group. Conclusion: Zhenwu Decoction has protective effects on heart and renal tissue of Type 2 CRS model rats. This effect may be achieved by increase uremic toxin excretion and ameliorating fibrosis.