Objective：To investigate the relationship of thyroid stimulating hormone(TSH) and metabolic syndrome(MS) with its components in different sexual subjects with normal euthyroid examination for preventing and curing metabolic syndrome and cardiovascular disease. Methods：We conducted a cross-sectional study of 10842 euthyroid subjects(male 7250，female 3592). Height，weight，blood glucose，blood pressure(SBP，DBP)，blood lipid(TC，TG，HDL，LDL)，uric acid，renal function and thyroid function，body mass index(BMI)，estimated glomerular filtration rate(GFR) were mesured. The relationship between TSH and MS was analyzed.Results：The prevalence of MS in male and female was 20.1% and 9.4%，respectively，and the TSH level in MS group was significantly higher than that in non MS group(male P=0.049；female P=0.009). Subjects were stratified according to quartiles of TSH level. The higher the TSH，the higher the prevalence of MS. With the increase of TSH，abnormal metabolism components also significantly increased (male P=0.05；female P=0.00). In males，TSH and TG，SBP was positively correlated(P=0.009，0.018). In females，TSH and SBP，DBP，TG，BMI were positively correlated(P=0.000，0.008，0，0)，and HDL was negatively correlated(P=0.022).Logistic regression analysis showed that the TSH level was the independent risk factor for MS in male subjects after adjusting for age，uric acid，blood glucose and blood lipids(P=0.043). Conclusion：In the subjects with normal euthyroid function，especially male， the increase of TSH level may be related to the increase risk of MS，and then increase the risk of cardiovascular disease.