Objective：To investigate the expressions of LRPPRC and Bcl-2 in prostate cancer，and the effects of LRPPRC on apoptosis. Methods：Immunohistochemistry was performed to analyze the expressions of LRPPRC and Bcl-2 on 198 prostate cancer tissues. The correlation between LRPPRC and Bcl-2 expressions was analyzed. The relationship between LRPPRC and Bcl-2 expressions and prognosis was analyzed. siRNA LRPPRC was used to transfect prostate cancer cells to decrease the level of LRPPRC，and the effects on proliferation，apoptosis，the expressions of Bcl-2，Bax and caspase-3 protein were observed. Results：Prostate cancer and prostate hyperplasia tissues highly expressed LRPPRC in 61.6%(122/198) and 18.0%(18/100) of patients，respectively(P＜0.001). Prostate cancer and prostate hyperplasia tissues highly expressed Bcl-2 in 49.5%(98/198) and 45.0%(45/100) of patients，respectively(P=0.539). A significant association between the expressions of LRPPRC and Bcl-2 was observed(r=0.179；P=0.012). High expression of LRPPRC combined with Bcl-2 was related with shorter biochemical progress(BCP)-free survival and overall survival(P＜0.001). When LRPPRC level being down-regulated by siRNA，the survival rate of prostate cancer cells was decreased，the apoptosis rate was increased，Bcl-2 protein level was decreased，and cleaved caspase-3 protein level was increased. There were no significant effects on Bax expression. Conclusion：LRPPRC expression was increased in prostate cancer tissues. LRPPRC may inhibit endogenous apoptosis of prostate cancer cells. The effect may be related with regulating Bcl-2 expression.