明胶-聚苯胺导电水凝胶的制备与研究
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国家自然科学基金(81670967);江苏省卫生厅面上项目(H201504);江苏省“六大人才高峰”第八批高层次人才项目(WSW-021)


Properties of electroactive gelatin-graft-polyaniline hydrogel
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    摘要:

    目的: 明胶-聚苯胺接枝共聚物(gelatin-graft-polyaniline, GP)导电水凝胶的制备和性能研究。方法: 采用直接掺杂法制作GP,使用樟脑磺酸(camphor sulfonic acid, CSA)作为掺杂剂。GP溶于水形成导电水凝胶(gelatin-graft-polyaniline hydrogel, GPH),以1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐[1-(3-dimethylaminoproply)-3-ethylcarbodiimide, EDC]进行交联。对制备的GP和GPH的形态结构、生物相容性、溶解性、溶胀比和导电性能进行观察研究。结果: GPH导电性能良好(1×10-4~1×10-3 S/cm),并随着苯胺含量的增大而增大。但当苯胺的量提高到一定程度,通过明胶共聚获得的GPH溶解性大大降低,同时溶胀比增加。结论: GPH是一种新型的可降解生物材料,具有良好的导电性能,作为支架在组织工程修复中有巨大的应用前景。

    Abstract:

    Objective: To study the preparation and properties of gelatin-graft-polyaniline(GP) hydrogel. Methods: GP was synthesized by direct doping technique, and camphor sulfonic acid(CSA) was used as dopant. The copolymer was dissolved in water and then cross-linked by EDC. The morphology and chemical feature, swelling ratios, dissolubility, biocompatibility and conductivity of GP hydrogels(GPH) were observed. Results: GPH had good conductivities (1×10-4~10-3 S/cm). The electrical property was enhanced with the content of polyaniline. Nonetheless, when the amount of polyaniline improved to a certain degree, the solubility was greatly reduced and swelling ratio was increased at the same time. Conclusion: GPH is a biodegradable conductive material and has great application prospects in tissue engineering.

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吴天一,卜寿山,庄 海,尤 莹,张继生,许 扬.明胶-聚苯胺导电水凝胶的制备与研究[J].南京医科大学学报(自然科学版),2017,(9):1173-1176,1184

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  • 收稿日期:2017-03-27
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  • 在线发布日期: 2017-09-25
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