Objective:To assess the association between miRNA-146a rs2910164 polymorphism and HCC risk by a meta-analysis. Methods:A systematical search of studies was conducted in papers published in PubMed , Embase ,Web of Science, China National Knowledge Infrastructure(CNKI) and Chinese Biomedical Literature Database(CBM) databases before January 30, 2017. Odds ratios(OR) and 95% confidence intervals（95% CI） were used to evaluate the association between miRNA-146a polymorphism and HCC risk. Results:A total of 18 case-control studies involving 5 657 cases and 6 680 healthy controls were included in this meta-analysis, in which no association was found between miRNA-146a rs2910164 polymorphism and HCC risk in any genetic models(C versus G：OR=0.96, 95%CI=0.88～1.06；GC versus GG：OR=0.98，95%CI=0.88～1.09；CC versus GG：OR=0.90，95%CI=0.74～1.09；GC/CC versus GG：OR=0.95，95%CI=0.82～1.10；CC versus GC/GG：OR=0.95，95%CI=0.84～1.07). Conclusion: No sufficient evidence supports the association between miRNA-146a rs2910164 polymorphism with hepatocellular cacinoma risk. The conclusion should be verified in large-scale and well-designed studies in the future.