食管鳞状细胞癌中血管生成素样蛋白2的表达及其临床意义
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

江苏省六大人才高峰项目(2016-WSW-015)


Angiopoietin-like protein 2 acts as a novel biomarker for diagnosis in patients with esophageal cancer
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨血管生成素样蛋白2(angiopoietin-like protein2, ANGPTL2)在食管鳞状细胞癌(esophageal squamous cell cancer,ESCC)组织中的表达及其临床意义。方法:采用免疫组化检测ESCC 组织中ANGPTL2的表达水平;通过酶联免疫吸附法检测食管癌患者和健康对照人群血清中ANGPTL2浓度。结果:与癌旁组织相比,ESCC 组织中ANGPTL2的表达明显升高(P<0.001);与健康对照人群相比,食管癌患者血清中ANGPTL2浓度明显升高。通过分析临床数据发现高表达的ANGPTL2 与肿瘤体积、淋巴结转移、TNM分期紧密相关。血清ANGPTL2浓度也与淋巴结转移、TNM分期等呈正相关。结论:ANGPTL2在ESCC的增殖和侵袭过程中有重要作用。血清ANGPTL2可以作为诊断ESCC潜在有效的血清标志物。

    Abstract:

    Objective: To detect the expression level of angiopoietin-like protein2(ANGPTL2) in esophageal squamous cell cancer (ESCC) tissues and investigate the clinical value for diagnosis. Methods:Immunohistochemistry(IHC) was used to determine the relative ANGPTL2 expression levels in ESCC tissues, and enzyme-linked immunosorbent assays were used to measure the levels of ANGPTL2. Results: Compared with controls, ANGPTL2 expression levels were significantly up-regulated in ESCC tissues and serum (P<0.001). Higher expression level of ANGPTL2 was found associated with larger tumor size, more lymph node metastasis and TNM stage. ELISA assay showed that serum ANGPTL2 was significantly elevated in ESCC patients and positively associated with high T-stage, high TNM stage and lymph node metastasis. Conclusion: ANGPTL2 plays a crucial role in proliferation and invasion of ESCC. Serum ANGPTL2 has potential value for early detection of ESCC.

    参考文献
    相似文献
    引证文献
引用本文

程 亮,于 裕,张 颖.食管鳞状细胞癌中血管生成素样蛋白2的表达及其临床意义[J].南京医科大学学报(自然科学版),2017,(11):1398-1401

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2017-04-19
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2017-12-06
  • 出版日期:
通知关闭
郑重声明