口腔扁平苔藓组织中CD3+、CD8+T细胞浸润与不典型增生的关系
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江苏高校优势学科(2014-37);国家自然科学基金面上项目(81771074);江苏省自然科学基金面上项目(BK20171483);江苏省口腔疾病研究重点实验室开放课题基金(JSKLOD-KF-1702)


Relationship between CD3+ T cell and CD8+ T cell infiltration and atypical hyperplasia in oral lichen planus
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    摘要:

    目的:探讨口腔扁平苔藓(OLP)中CD3+T细胞和CD8+T细胞浸润与OLP伴上皮不典型增生的相关性,为OLP的临床诊断和免疫治疗提供新的方向。方法:采用免疫组化半定量法检测CD3+、CD8+T细胞在79例OLP患者组织中的表达,取10例口腔正常黏膜组织作为对照,分析口腔扁平苔藓组织中CD3+、CD8+T细胞浸润与不典型增生的关系。结果:CD3+、CD8+T细胞在正常口腔黏膜组织中呈阴性表达,在79例OLP中均呈阳性表达。CD3+、CD8+T细胞浸润与患者性别、年龄、发生部位无明显统计学意义,但是与OLP伴上皮不典型增生密切相关,具有统计学意义(P<0.001,P=0.002),CD3+T细胞浸润和CD8+T细胞浸润之间具有显著相关性(r=0.498,P<0.001)。结论:口腔扁平苔藓患者组织中CD3+、CD8+T细胞浸润与上皮不典型增生密切相关,影响OLP的发生发展。

    Abstract:

    Objective:To investigate the relationship between CD3+ T cells and CD8+ T cells infiltration and atypical hyperplasia in oral lichen planus (OLP) , which will provide a new direction for the clinical diagnosis and immunotherapy of OLP. Methods:Immunohistochemical semi-quantitative method was used to detect the CD3+ T cells and CD8+ T cells infiltration in 79 cases of OLP patients, meanwhile 10 cases of normal oral mucosa as a control. The relationship between these T cell infiltration and atypical hyperplasia in OLP was analyzed by statistical methods. Results:CD3+ T cells and CD8+ T cells were negatively expressed in normal oral mucosa, but were positively expressed in 79 cases of OLP. The infiltration of CD3+ T cells and CD8+ T cells had no relationship with gender, age or the location of OLP, but they were closely correlated with the atypical hyperplasia of OLP(P<0.001 and P=0.002, respectively), the infiltration of CD3+ T cells were positively associated with the infiltration of CD8+ T cells(r=0.498,P<0.001). Conclusions:The infiltration of CD3+ T cells and CD8+ T cells is closely related to epithelial dysplasia, which affects the occurrence and development of OLP.

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朱丽芳,潘 璐,郑阳玉,徐双波,刘来奎,徐 艳.口腔扁平苔藓组织中CD3+、CD8+T细胞浸润与不典型增生的关系[J].南京医科大学学报(自然科学版),2017,(12):1663-1667

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  • 收稿日期:2017-07-19
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  • 在线发布日期: 2017-12-25
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