Objective: To use of modified Politzer device in the management of chronic otitis media with effusion(OME) in children and evaluate the clinical efficacy. Methods: Forty-three Children diagnosed with bilateral chronic OME and hearing loss were randomly divided into A and B groups. Tweenty-two Children in group A, aged 4~11 years started as the treatment group underwent modified Politzer device for inflation. Another 21 Children in group B, aged 5~12 years were included as the control group underwent careful observation. After 4 weeks, a cross-over was performed. Both groups underwent otoendoscopy, tympanometry and audiometry at inclusion and after 4 and 8 weeks for evaluating the treatment efficacy. Results: In group A, the middle ear pressure and pure tone threshold were normalized in 20(45% )and improved in 14(32%) ears after 4 weeks treatment. While in B group, 6(14%) ears were normalized and 4 ears were improved(10%) . Statistically significant differences were demonstrated between children with modified Politzer device for inflation and children with observation. After cross-over , 17(40%) normalization and 13(31%) improvement of ears were achieved in B group, and 24(55%) normalization and 14(32%) improvement of ears were achieved in A group. Statistically differences were demonstrated between two groups (P＜0.05). There were 8(19%) children were submitted to grommet surgery after 8 weeks treatment. in two groups. Conclusion: Efficiency were demonstrated in children with chronic OME inflated with Modified Politzer. The earlier treatments were given, the better effects could be achieved. It can reduce the need for surgery.