Wnt信号通路与mCRC含伊立替康化疗疗效及预后的易感性研究
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国家自然科学基金(81773516);江苏省高校优势学科建设资助(公共卫生与预防医学)


Wnt signaling pathway and the susceptibility of curative effect and prognostic of mCRC patients received irinotecan⁃based chemotherapy
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    摘要:

    目的:探讨Wnt信号通路关键基因单核苷酸多态性(single nucleotide polymorphisms,SNPs)与转移性结直肠癌(metastatic colorectal cancer,mCRC)含伊立替康化疗疗效及预后的相关性。方法:筛选Wnt信号通路上的关键基因,对110例含伊立替康化疗的mCRC患者进行SNPs分型。运用Logistic和Cox回归法分别分析SNPs不同基因型对疗效及预后的影响。结果:LRP6 rs10772542 C等位基因患者的疾病控制率(disease control rate,DCR)相对于T等位基因更低(OR=2.49,95%CI=1.28~4.83,P=0.007)。LEF1 rs749414 G等位基因的无进展生存期(progression-free survival,PFS)相对于T等位基因更长(HR=0.55,95%CI=0.40~0.78,P=0.001);WNT7B rs10448605 T等位基因的PFS相对于C等位基因更短(HR=1.65,95%CI=1.13~2.41,P=0.009);而WNT2 rs2239957 C等位基因的总生存期(overall survival,OS)相对于G等位基因更长(HR=0.54,95%CI=0.35~0.85,P=0.007)。结论:Wnt信号通路上的LRP6、LEF1、WNT7B和WNT2基因多态性与mCRC含伊立替康化疗疗效及预后之间存在明显的相关性。

    Abstract:

    Objective:To explore the association between single nucleotide polymorphisms(SNPs)in the Wnt signaling pathway genes and the curative effect and prognostic of metastatic colorectal cancer(mCRC)patients who received irinotecan-based chemotherapy. Methods:We selected seven key genes in the Wnt signaling pathway and genotyped the SNPs within seven genes among 110 mCRC patients treated with irinotecan-based chemotherapy. Logistic regression and cox regression analysis were performed to evaluate the association between SNPs and the curative effect and prognostic of mCRC patients. Results:Patients with the LRP6 rs10772542 C alleles had a lower disease control rate(DCR)compared with those with T alleles(OR=2.49,95%CI=1.28~4.83,P=0.007). LEF1 rs749414 G alleles had a longer progression-free survival(PFS)compared with the T alleles(HR=0.55,95%CI=0.40~0.78,P=0.001)and WNT7B rs10448605 T alleles had a shorter PFS compared with the C alleles(HR=1.65,95%CI=1.13~2.41,P=0.009). Furthermore,WNT2 rs2239957 C alleles had a longer overall survival(OS)compared with the G alleles(HR=0.54,95%CI=0.35~0.85,P=0.007). Conclusion:Genetic variants in the Wnt signaling pathway genes contribute to the curative effect and prognostic of mCRC patients who received irinotecan-based chemotherapy.

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曹 玲,谢利生,黎书炜,杜牧龙,顾冬英,张正东,王美林. Wnt信号通路与mCRC含伊立替康化疗疗效及预后的易感性研究[J].南京医科大学学报(自然科学版),2018,(2):195-200

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  • 收稿日期:2017-03-23
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  • 在线发布日期: 2018-03-02
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