Study on the mechanisms of the variation of serum uric acid in obese patients with different body mass index obesity class
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摘要:
目的：探讨不同体重指数（body mass index，BMI）肥胖患者血尿酸的变化及发生机制。方法：入选269例在上海市第十人民医院就诊的肥胖患者［BMI≥28 kg/m2］，按照BMI分成轻度、中度和重度肥胖组。检测和计算各组患者的血尿酸水平、人体测量学和代谢指标，各组间进行比较，并把血尿酸与各检测指标进行相关性分析。结果：肥胖患者的血尿酸水平随BMI升高而升高，男性肥胖患者尿酸水平显著高于女性肥胖患者（P < 0.05）。肥胖患者高尿酸血症的患病率也随BMI增加呈上升趋势，重度肥胖组高尿酸血症的比例均超过了70%。肥胖患者血尿酸均与BMI、空腹胰岛素、胰岛素抵抗指数和白介素-6呈正相关。结论：肥胖患者的血尿酸水平和高尿酸血症发生率随BMI升高而升高，高尿酸血症的发生与BMI、胰岛素抵抗和炎症因子密切相关。
Abstract:
Objective：To assess the mechanism of the variation of serum uric acid in obese patients with different body mass index（BMI）. Methods：Retrospective analysis was performed in 269 obesity patients with BMI≥28 kg/m2 from the authors’ affiliated hospital. According to their BMI，they were respectively divided into three groups，including the mild，moderate and severe obesity groups. Serum uric acid，anthropometric and metabolic characteristics of patients were measured. Each group was compared and the correlation between serum uric acid level and other index was analyzed. Results：The serum uric acid levels in all the obesity patients were increased with the increasing BMI，and which in male obesity were higher than that in female obesity（P < 0.05）. The prevalence of hyperuricemia in these obese patients also increased with BMI，which in male and female severe obesity patients were both more than 70%. Serum uric acid in all obese patients was positively correlated with BMI，fasting insulin，HOMA-IR and IL-6. Conclusion：Serum uric acid levels and the prevalence of hyperuricemia were both increased with the increasing BMI. Hyperuricemia is positively correlated with BMI，insulin resistance and inflammatory factors.
