Colorectal cancer is a common digestive system disease with the increasing morbidity in the past 30 years. However，the pathogenesis of it remains unclear. Researches indicate that the occurrence of colorectal cancer is related to many factors such as heredity，diet，and inflammation. At present，chemopreventive drugs targeted at colorectal cancer show surprising results in clinical studies. These drugs are found to protect the body from chemical carcinogens and exert cancer prevention effect by promoting the expression of biphasic detoxification enzymes and antioxidant enzyme genes in the promotor region of nuclear factor E2 related factors. This article will review the latest researches in nuclear factor E2 related factor2 as a chemopreventive target in colorectal cancer.