Cholangiocarcinoma is a malignant tumor originating from the bile duct epithelium with a poor prognosis. At present，the specific molecular mechanism of cholangiocarcinoma is not clear，and the previous studies have focused on gene mutations in the histological level of cholangiocarcinoma. However，more and more studies have found that the development of cholangiocarcinoma is not only caused by the changes of DNA. Epigenetic regulations，such as DNA methylation，histone modification，chromatin remodeling，non-coding RNA and genetic imprinting regulation also play an important role on development of cholangiocarcinoma，which receive more attention now. We summarize the current epigenetic progress of cholangiocarcinoma，and aims to reveal the role of epigenetic regulation in the development and progression of cholangiocarcinoma.