Objective：To detect the expression and function of Kv1.3 channel in peripheral blood T lymphocytes of asthma patients，to study the effect of Kv1.3 channel blockers on the proliferation of T lymphocytes and the production of Th2 cytokines in peripheral blood of asthmatic patients，and to explore the possibility of Kv1.3 channel blockers in treating chronic airway inflammation in patients with asthma. Methods：T lymphocytes were isolated from peripheral blood of asthma patients and healthy controls. Then，we detected the mRNA levels of Kv1.3 in T cells. We detected the effect of Kv1.3 channel inhibitors ShK on T cell proliferation and the production of Th2 cytokines. Results：The Kv1.3 level of peripheral blood T lymphocytes in patients with asthma was significantly higher than that of healthy controls. ShK significantly inhibited the proliferation and Th2 cytokines production ability of T lymphocytes. Conclusion：Kv1.3 may play important roles in inflammation in asthma. Selective blocking of Kv1.3 channels may be one of the future treatments of asthma.