血清斯钙素⁃1在稳定期慢性阻塞性肺病中的表达及意义
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Expression and role of serum stanniocalcin⁃1 in chronic obstructive pulmonary disease
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    摘要:

    目的:探讨斯钙素-1(stanniocalcin-1,STC1)在稳定期慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)患者血清中的表达及意义。方法:收集55例稳定期COPD患者,根据肺功能和问卷评分进行相应分组,且以24例健康者作为对照。采用酶联免疫吸附法(ELISA)测定各研究对象的血清斯钙素-1表达情况,进行相关分析。结果:①与健康对照组相比,稳定期COPD患者血清斯钙素-1表达水平明显降低(P < 0.05)。②血清斯钙素-1在初筛COPD上具有一定价值(P=0.025,AUC=0.659),最佳阈值为1 350 pg/mL(敏感度81.82%;特异度50.00%)。③血清斯钙素-1与稳定期COPD患者病情严重程度[包括GOLD分级、慢阻肺评估测试(COPD assessment test,CAT)评分、ABCD分组、肺功能]无明显相关性。结论:血清斯钙素-1在COPD中显著降低,可能对于COPD的诊治具有一定临床意义。

    Abstract:

    Objective:To investigate the serum level of stanniocalcin-1(STC1) in patients with stable chronic obstructive pulmonary diseases(COPD) and to explore the relationship between STC1 and severity of the disease. Method:A total of 55 patients with definite stable COPD and 24 healthy controls were enrolled in this study. Serum STC1 was measured by enzyme-linked immunosorbent assay(ELISA),and the correlation between STC1 and COPD was analyzed. Results:①Serum STC1 levels were significantly lower in patients with COPD than healthy controls(P < 0.05). ②The receiver-operating characteristic(ROC) curve of serum SCT1 was used for threshold identification(AUC=0.659,P=0.025),the optimal cut-off point of serum STC1 was 1 350 pg/mL(sensitivity 81.82%,specificity 50.00%,respectively). ③Poor association of serum STC1 levels with stable COPD was found,including the GOLD classification,COPD assessment test(CAT) scores and lung functions. Conclusion:Serum STC1 levels were significantly decreased in COPD patients while it is poorly correlated with disease severity. STC1 might have clinical application in stable COPD.

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何淑娟,许家艳,贾 嫚,欧英炜,周 军,姚 欣.血清斯钙素⁃1在稳定期慢性阻塞性肺病中的表达及意义[J].南京医科大学学报(自然科学版),2018,(10):1404-1408

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  • 收稿日期:2018-08-20
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  • 在线发布日期: 2018-11-08
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