Association of genetic variations of LncRNA PRNCR1 and risk of gastric cancer
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摘要:
目的：探讨LncRNA PRNCR1（prostate cancer non-coding RNA 1）相关的4个基因多态性位点与胃癌发病风险及病理特征的相关性。方法：研究纳入300例经病理确诊的胃癌患者和300例健康者进行病例对照研究；基因分型采用Mass-array基因分析平台完成；采用酶联免疫吸附实验（ELISA）检测幽门螺杆菌（H. pylori）感染状态。结果：LncRNA PRNCR1 rs16901946位点的基因型分布在对照组及病例组中有显著性差异（P=0.018）。与野生型AA基因型相比，rs16901946位点AG基因型（AG vs. AA：校正后OR=1.41，95%CI：1.00~1.98，P=0.048）、GG基因型（GG vs. AA：校正后OR=2.57，95%CI：1.15~5.75，P=0.022）及AG/GG基因型（AG/GG vs. AA：校正后OR=1.51，95%CI：1.09~2.09，P=0.014）的胃癌相对发病风险较高。亚组分析显示，该位点在男性（AG/GG vs. AA：校正后OR=1.82，95%CI：1.23~2.69，P=0.003）、在H. pylori感染人群（AG/GG vs. AA：校正后OR=1.83，95%CI：1.16~2.89，P=0.009）发病风险相对较高。对肿瘤病理特征进行亚组分析显示，该位点与贲门癌的发病风险相关（AG/GG vs. AA：校正后OR=1.58，95%CI：1.10~2.28，P=0.011）、早期胃癌风险相关（AG/GG vs. AA：校正后OR=1.88，95%CI：1.18~2.98，P=0.008）。结论：lncRNA PRNCR1 rs16901946的遗传多态性位点与胃癌发病风险相关，在男性及H. pylori感染阳性人群中的相对风险高。
Abstract:
Objective：To investigate the susceptibility of four genetic variations of prostate cancer non-coding RNA 1（LncRNA PRNCR1）to the risk and pathological characteristics of gastric cancer. Methods：A total of 300 gastric cancer cases and 300 health controls were enrolled in this case-control study. The Mass-array gene analysis platform was applied to genotype the enrolled participants. Enzyme-linked immunosorbent assay was used to detect the H. pylori infection. Results：There were significant differences of LncRNA PRNCR1 rs16901946 genotypes distribution between the cases and the control group（P=0.018），and the AG（ORadjusted=1.41，95%CI：1.00-1.98，P=0.048），GG（ORadjusted=2.57，95%CI：1.15-5.75，P=0.022）and AG/GG genotype（ORadjusted=1.51，95%CI：1.09-2.09，P=0.014）were associated with increased risk of gastric cancer，respectively. The results of subgroup analysis showed that LncRNA PRNCR1 rs16901946 was associated with the risk of gastric cancer in the subgroup of male（AG/GG vs. AA：ORadjusted=1.82，95% CI：1.23-2.69，P=0.003），and individuals with H. pylori infection（AG/GG vs. AA：ORadjusted=1.83，95%CI：1.16-2.89，P=0.009）. In addition，LncRNA PRNCR1 rs16901946 was associated with risk of cardia cancer（AG/GG vs. AA：ORadjusted=1.58，95% CI：1.10-2.28，P=0.011）. Similarly it was associated with risk of gastric cancer in clinical stage T1-T2（AG/GG vs. AA：ORadjusted=1.88，95%CI：1.18-2.98，P=0.008）but not in T3-T4. Conclusion：This study indicates that LncRNA PRNCR1 rs16901946 is associated with the increased risk of gastric cancer，especially for male and individuals with H. pylori infection.
