Pol ι表达水平对行食管癌术后辅助放疗患者的生存影响
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国家自然科学基金(81372433,81672975);江苏省333人才项目(BRA2016071);江苏省六大人才高峰项目(WSN?095)


The effect of Pol ι expression on overall survival of ESCC patients with postoperative adjuvant radiotherapy
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    摘要:

    目的:探讨DNA 聚合酶 ι(DNA polymerase ι,Pol ι)表达水平对行食管癌术后辅助放疗患者的生存影响。方法:采用免疫组化方法检测97例行术后辅助放疗的食管癌患者组织中Pol ι的表达情况,分析Pol ι表达水平对这些患者生存的影响。结果:20例食管癌患者组织中Pol ι呈低表达,77例食管癌患者组织中Pol ι呈高表达;生存曲线显示Pol ι表达水平与行术后辅助放疗的食管癌患者生存呈负相关;COX回归分析显示Pol ι表达水平是影响食管癌根治术后辅助放疗患者生存的独立预后因素。结论:Pol ι可能是判断行食管癌术后辅助放疗患者预后的潜在分子标志物。

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    Objective:To investigate the effect of Pol ι expression on overall survival of esophageal squamous-cell carcinom(ESCC) patients with postoperative adjuvant radiotherapy. Methods:The correlation between Pol ι expression and overall survival of 97 ESCC patients with postoperative adjuvant radiotherapy was analyzed using immunohistochemical method. Results:There were 20 cases with low expression of Pol ι and 77 cases with high expression of Pol ι in these patients. Survival curve showed Pol ι expression was negatively correlated with overall survival of ESCC patients with postoperative adjuvant radiotherapy,and COX regression analysis indicated that Pol ι expression was one of the independent prognostic factors of postoperative adjuvant radiotherapy for esophageal cancer. Conclusion:Pol ι may be a potential molecular markers for postoperative adjuvant radiotherapy in esophageal cancer.

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周俊东,宁忠华,邹士涛,刘 标,吴锦昌. Pol ι表达水平对行食管癌术后辅助放疗患者的生存影响[J].南京医科大学学报(自然科学版),2018,(11):1525-1527,1544

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  • 收稿日期:2017-12-13
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  • 在线发布日期: 2018-12-03
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