新诊断2型糖尿病患者合并高尿酸血症的危险因素分析
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Analysis on risk factors of hyperuricemia in patients with newly diagnosed type 2 diabetes
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    摘要:

    目的:探讨新诊断2型糖尿病(type 2 diabetes mellitus,T2DM)患者合并高尿酸血症(hyperuricemia,HUA)的危险因素。方法:纳入2010年3月—2017年3月在南京医科大学第一附属医院内分泌科新诊断的T2DM患者735例,收集患者的一般临床资料和生化指标,分析影响血尿酸水平的相关因素。结果:合并高尿酸血症(T2DM+HUA)的患者110例(合并HUA组),不合并HUA的T2DM患者625例(无HUA组)。合并HUA组患者的年龄、脂蛋白a和估算肾小球滤过率(estimated glomerular filtration rate,eGFR)明显低于无HUA组(P<0.05),而合并HUA组体重指数(body mass index,BMI)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartic transaminase,AST)、谷氨酰转肽酶(gamma-glutamyltransferase,GGT)、甘油三酯(triglyceride,TG)、肌酐(creatinine,Cr)以及视黄醇结合蛋白(retinol binding protein,RBP)明显高于无HUA组,差异有统计学意义(P<0.05)。Logistic回归分析发现男性、较低年龄、高BMI、高TG、低eGFR是新诊断T2DM合并HUA的危险因素。结论:新诊断T2DM患者中,相对年轻、超重、伴高TG血症、低eGFR的男性更要关注HUA的综合管理。

    Abstract:

    Objective:To analyze risk factors of hyperuricemia(HUA)in patients with newly diagnosed type 2 diabetes mellitus(T2DM). Methods:A total of 735 patients with newly-diagnosed T2DM from the First Affiliated Hospital of NMU were enrolled in this case-control study from March 2010 to March 2017. The general clinical data and biochemical indicators of the patients were collected,and the related factors affecting the level of serum uric acid were analyzed. Results:The patients were divided into two groups according to with or without HUA,110 patients with HUA while 625 patients without HUA. The age,lipoprotein A,and estimated glomerular filtration rate(eGFR)in the T2DM with HUA group were all significantly lower than those patients without HUA(P<0.05). Besides,the body mass index(BMI),alanine aminotransferase(ALT),aspartic transaminase(AST),gamma-glutamyl transpeptidase(γGGT),triglyceride(TG),creatinine(Cr)and retinol binding protein(RBP)of the T2DM with HUA group were significantly higher than those of T2DM without HUA group(P<0.05). Logistic regression analysis revealed that male,low age,high BMI,high TG and low eGFR in the newly diagnosed T2DM patients were independent risk factors complicated with HUA. Conclusion:In the newly diagnosed T2DM patients,males who were relatively young,overweight,with hypertriglyceridemia and low eGFR,should be paid more attention on the comprehensive management of hyperuricemia.

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倪 娟,刘 康,邬步云,马向华,邢昌赢,毛慧娟.新诊断2型糖尿病患者合并高尿酸血症的危险因素分析[J].南京医科大学学报(自然科学版),2018,(11):1540-1544

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  • 收稿日期:2018-07-08
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  • 在线发布日期: 2018-12-03
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