T2 mapping眼外肌定量测量在甲状腺相关眼病诊断和分期中的应用价值
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国家自然科学基金(81801659)


Clinical value of quantitative measurements of extraocular muscles with T2 mapping in the diagnosis and staging of thyroid⁃associated ophthalmopathy
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    摘要:

    目的:探讨T2 mapping眼外肌定量测量在甲状腺相关眼病(thyroid-associated ophthalmopathy,TAO)诊断和分期中的价值。方法:对36例TAO患者及28例健康志愿者行眼眶T2 mapping检查,测量眼外肌的T2弛豫时间(T2 relaxation time,T2RT)值。比较病例组与正常对照组、活动期组与非活动期组眼外肌T2RT值的差异。采用受试者工作特征曲线(ROC曲线)法评估其判断TAO活动性的诊断价值。结果:病例组眼外肌的T2RT值明显大于正常对照组(P<0.001)。活动期组眼外肌的T2RT值明显大于非活动期组(P<0.001)。ROC结果显示以眼外肌T2RT值≥116.5 ms判断TAO处于活动期的诊断效能最优(曲线下面积0.863,敏感度75.0%,特异度93.8%)。结论:基于T2 mapping的眼外肌定量测量可辅助TAO的诊断和分期。

    Abstract:

    Objective:To investigate the clinical value of quantitative measurements of extraocular muscles with T2 mapping in the diagnosis and staging of thyroid-associated ophthalmopathy(TAO). Methods:Thirty-six patients with TAO and 28 healthy controls(HCs)were enrolled in our study and evaluated using T2 mapping imaging. The hotspot T2 relaxation time(T2RT)values of the most inflamed extraocular muscles were measured,and compared between the TAOs and the HCs groups,as well as the active TAOs and the inactive TAOs groups. Receiver operating characteristic(ROC)analysis was performed to evaluate the diagnostic value of T2RT for discriminating active TAOs from inactive TAOs. Results:The T2RT values of extraocular muscles in TAOs were significantly higher than those in HCs(P < 0.001). The T2RT values of extraocular muscles in active TAOs were significantly higher than those in inactive TAOs(P < 0.001). ROC results indicated that,optimal staging efficacy(area under the curve,0.863;sensitivity,75.0%;specificity,93.8%)for differentiating active TAOs from inactive TAOs could be obtained,when setting 116.5 ms as the cutoff T2RT value of extraocular muscles. Conclusion:Quantitative measurements of extraocular muscles with T2 mapping could assist in the diagnosis and staging of TAO.

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陈 文,胡 昊,许晓泉,苏国义,陈欢欢,吴飞云. T2 mapping眼外肌定量测量在甲状腺相关眼病诊断和分期中的应用价值[J].南京医科大学学报(自然科学版),2019,(1):141-144

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  • 收稿日期:2018-11-05
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  • 在线发布日期: 2019-02-21
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