Objective：To detect the expression of TRAF7 in normal brain tissue and glioblastoma，and further analyze the effect of TRAF7 on proliferation and migration of glioblastoma cells. Methods：Expression of TRAF7 in normal brain tissue and glioblastomas were analyzed in the Chinese Glioblastoma Genome Project（CGGA）Database. The small interfering RNA of TRAF7（si-TRAF7）was transfected into U87 and LN229 glioblastoma cells to downregulate the expression level of TRAF7. The CCK8 assay，colony formation assay and scratch assay were performed to observe the changes of proliferation and migration ability of glioblastoma cells. Results：The expression of TRAF7 in glioblastomas was significantly higher than that in normal brain tissue. Compare to low-expression group of TRAF7，poor prognosis was observed in high-expression group of TRAF7 in glioblastoma patients. Down-regulation of TRAF7 inhibit the proliferation and migration of glioblastoma cells. Conclusion：TRAF7 is highly expressed in glioblastomas，and its expression level is corelated with clinical prognosis in patients with glioblastomas. TRAF7 promotes proliferation and migration in glioblastoma cells.