Allogeneic bone material applies in preservation of tooth extraction sites in rabbits
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摘要:
目的：研究不同比例的松质骨、皮质骨及脱钙骨基质（demineralized bone matrix，DBM）混合的兔同种异体骨在拔牙位点保存中的效果。方法：24只新西兰大白兔随机分A、B、C、D 4组，随机拔除一侧下颌切牙。A组为对照组，拔牙后自然愈合，B、C、D组分别用兔同种异体骨1（松质骨∶皮质骨∶DBM质量比为0∶9∶1）、兔同种异体骨2（松质骨∶皮质骨∶DBM质量比为3∶6∶1）以及去蛋白牛骨矿物质（deproteinized bovine bone mineral，DBBM）骨粉进行拔牙位点保存。术后1、3个月检测拔牙窝高度与宽度的变化、Micro-CT扫描评价拔牙窝成骨情况。比较不同骨材料对牙槽嵴形态保存效果以及新骨形成情况。结果：拔牙后1、3个月，牙槽嵴顶高度降低的量为D组
Abstract:
Objective：To compare different proportions of rabbit allogeneic bone mixed with cancellous bone，cortical bone and demineralized bone matrix（DBM）in preservation of tooth extraction sites. Methods：A total of 24 New Zealand white rabbits were randomly assigned into A，B，C and D groups. The mandibular incisors were extracted on one side randomly. Group A was the blank control with tooth extraction healed naturally after treatment. Extraction sockets of group B，C，D were respectively filled with allograft bone 1（the weight ratio of cancellous bone：cortical bone：DBM=0∶9∶1），allograft bone 2（cancellous bone：cortical bone：DBM=3∶6∶1）and deproteinized bovine bone mineral（DBBM）. The morphological changes of the extraction sockets were evaluated. Micro-CT was taken 1 or 3 months after surgery to analyze the healing of sockets. The effect of different bone materials on the morphological preservation of alveolar ridge and the formation of new bone were compared. Results：The height reduction of alveolar ridge at 1 and 3 months after tooth extraction was D
