Association between ERCC1 gene polymorphisms and risk of pancreatic cancer：a Meta⁃analysis
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摘要:
目的：探讨切除修复交叉互补基因1（excision repair cross complementing 1，ERCC1）2种最常见的基因多态性（rs3212986、rs11615）与胰腺导管腺癌（pancreatic ductal adenocarcinoma，PDAC）患病风险的相关性。方法：检索PubMed、EMBASE、Web of Science、中国知网文献数据库，查找国内外关于ERCC1多态性（rs3212986、rs11615）与PDAC易感性关系的病例对照研究。由2名评价者根据纳入标准分别独立筛选文献并提取数据后，采用Stata12.0软件进行Meta分析。结果：共纳入8项病例对照研究，其中ERCC1 rs3212986纳入4项研究共1 934例患者，rs11615纳入4项研究共2 547例患者。结果显示，ERCC1 rs3212986可显著提高人群PDAC的患病风险（CA vs. AA：OR=1.34，95% CI：1.11~1.63；CC vs. AA：OR=2.33，95% CI：1.73~3.14；AC+CC vs. AA：OR=1.50，95% CI：1.25~1.80；CC vs. CA+AA：OR=1.98，95% CI：1.50~2.62；C vs. A：OR=1.45，95% CI：1.27~1.66）；而ERCC1 rs11615则与PDAC患病风险无关（CT vs. TT：OR=1.02，95% CI：0.87~1.21；CC vs. TT：OR=1.21；95% CI：0.93~1.56；TC+CC vs. TT：OR=1.06，95% CI：0.91~1.24；CC vs. CT+TT：OR=1.20，95% CI：0.94~1.53；C vs. T：OR=1.08，95% CI：0.96~1.21）。结论：ERCC1 rs3212986可明显增加PDAC发病风险，rs11615则与PDAC易感性无关。
Abstract:
Objective：This study aims to assess the association between excision repair cross complementing 1（ERCC1）gene polymorphisms（rs3212986、rs11615）and susceptibility to pancreatic ductal adenocarcinoma. Methods：Evidence for this association was obtained by searching PubMed，Web of Science，EMBASE and CNKI. Data were extracted using standardized forms and odds ratios（ORs）with 95% confidence intervals（CIs）were used to assess the strength of association. All statistical analyses were performed using Stata 12.0. Results：Eight studies were enrolled in our final combined analysis. The results showed evidence for significant association between rs3212986 polymorphism and PDAC risk（CA vs. AA：OR=1.34，95% CI：1.11-1.63；CC vs. AA：OR=2.33，95% CI：1.73-3.14；AC+CC vs. AA：OR=1.50，95% CI：1.25-1.80；CC vs. CA+AA：OR=1.98，95% CI：1.50-2.62；C vs. A：OR=1.45，95% CI：1.27-1.66）. However，no association was observed between rs11615 and PDAC risk（CT vs. TT：OR=1.02，95% CI：0.87-1.21；CC vs. TT：OR=1.21；95% CI：0.93-1.56；TC+CC vs. TT：OR=1.06，95% CI：0.91-1.24；CC vs. CT+TT：OR=1.20，95% CI：0.94-1.53；C vs. T：OR=1.08，95% CI：0.96-1.21）. Conclusion：The allele gene C of ERCC rs3212986 is significantly associated with the risk of PDAC，while rs11615 might not contribute to the risk of PDAC.
