双花百合片治疗糜烂型口腔扁平苔藓的疗效及安全性评价
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江苏省高等学校大学生实践创新训练计划省级重点项目(201310312018Z)


The effects and safety of Shuanghua Baihe Tablet in the treatment of erosive oral lichen planus
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    摘要:

    目的:探索双花百合片治疗糜烂型口腔扁平苔藓(erosive oral lichen planus,EOLP)的疗效及安全性,为EOLP的治疗提供更多思路和选择。方法:收集60例EOLP患者,随机分为两组。实验组服用双花百合片,对照组服用转移因子胶囊。在口服用药的同时两组患者均配合使用曲安奈德口腔软膏和西帕依固龈液。比较两组患者治疗1周前后临床症状及体征的变化,并对比服用双花百合片前及1周后EOLP患者血常规、肝肾功能等相关指标。结果:实验组和对照组治疗1周后糜烂面积缩小,疼痛减轻(P < 0.05)。实验组总有效率为93.3%,对照组为70.0%,两组间差异有统计学意义(P<0.05)。服用双花百合片的EOLP患者治疗前后的血常规及肝肾功能相关指标差值均无统计学意义(P>0.05)。结论:双花百合片相对于转移因子胶囊治疗EOLP的临床疗效更加显著,且临床使用具有良好的安全性。

    Abstract:

    Objective:This study aims to explore the clinical efficacy and safety of Shuanghua Baihe Tablet in treatment of erosive oral lichen planus(EOLP),and to provide more ideas and options for treatment of EOLP. Methods:Sixty EOLP patients were divided into two groups randomly. The experimental group was given Shuanghua Baihe Tablets,and the control group was given Transfer Factor Capsules. Both groups were treated with triamcinolone acetonide oral ointment and Xipayi mouth rinse at the same time. The changes of clinical symptoms and signs were compared before treatment and after treatment for one week between both groups. And indexes of blood,liver and renal function before and after treatment were compared. Results:EOLP patients in both of the experimental group and the control group had less erosion area and less pain after treatment of one week(P < 0.05). The total effective rate was 93.3% in the experimental group and 70.0% in the control group,and there were significant differences in the total effective rate between both groups(P<0.05). There was no significant difference in the related indexes of blood,liver and renal function before and after treatment in EOLP patients treated with Shuanghua Baihe Tablets(P > 0.05). Conclusion:Shuanghua Baihe Tablet is more effective than Transfer Factor Capsule in treatment of EOLP,and it is safe in clinical use.

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杭 慧,谷 庆,李留炀,钱 棱,吴国英.双花百合片治疗糜烂型口腔扁平苔藓的疗效及安全性评价[J].南京医科大学学报(自然科学版),2019,(9):1395-1398

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  • 收稿日期:2018-12-13
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  • 在线发布日期: 2019-09-29
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