危重症患者限制性输血策略的临床效果分析
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江西省教育厅科技技术研究青年项目(170144)


Expression and role of serum stanniocalcin⁃1 in chronic obstructive pulmonary disease
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    摘要:

    目的:评价危重症患者限制性输血与开放性输血的临床治疗效果。方法:回顾性分析南昌大学第二附属医院ICU 2017年8月—2018年7月进行红细胞输血治疗的危重症患者共101例,比较两种输血策略的临床治疗效果。结果:限制性输血组输血前血红蛋白(hemoglobin,Hb)值、输血后Hb值及红细胞输注量均明显低于开放性输血组水平(P < 0.05);限制性输血组的多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)评分、≥3个衰竭器官数及肺水肿发生率、心力衰竭发生率均低于开放性输血组(P < 0.05);临床转归方面,两组病死率和重症感染发生率的差异均无统计学意义(P > 0.05)。结论:ICU贫血患者限制性输血策略的临床效果优于开放性输血策略。

    Abstract:

    Objective:To investigate the serum level of stanniocalcin-1(STC1) in patients with stable chronic obstructive pulmonary diseases(COPD) and to explore the relationship between STC1 and severity of the disease. Method:A total of 55 patients with definite stable COPD and 24 healthy controls were enrolled in this study. Serum STC1 was measured by enzyme-linked immunosorbent assay(ELISA),and the correlation between STC1 and COPD was analyzed. Results:①Serum STC1 levels were significantly lower in patients with COPD than healthy controls(P < 0.05). ②The receiver-operating characteristic(ROC) curve of serum SCT1 was used for threshold identification(AUC=0.659,P=0.025),the optimal cut-off point of serum STC1 was 1 350 pg/mL(sensitivity 81.82%,specificity 50.00%,respectively). ③Poor association of serum STC1 levels with stable COPD was found,including the GOLD classification,COPD assessment test(CAT) scores and lung functions. Conclusion:Serum STC1 levels were significantly decreased in COPD patients while it is poorly correlated with disease severity. STC1 might have clinical application in stable COPD.

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黄 婷,龚晨辉,叶水文,余 玲,周 芬,饶美英.危重症患者限制性输血策略的临床效果分析[J].南京医科大学学报(自然科学版),2019,(10):1480-1482

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  • 收稿日期:2019-06-12
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  • 在线发布日期: 2019-11-01
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