Objective：This study aims to to assess the effect of BVT.2733，a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor，on energy metabolism and inflammation-related gene expression in hepatic，skeletal muscular，cardiac muscular，renal and splenic tissues in C57BL/6J mice. Methods：C57BL/6J mice were fed at a normal fat diet（NC）or high fat diet（HFD）. HFD treated mice were then administrated with BVT.2733（HFD+BVT）or vehicle（HFD）. We examined the effects of BVT.2733 on energy metabolism-related genes and typical inflammatory genes expression in hepatic，skeletal muscular，cardiac muscular，and renal tissues by RT-PCR. Results：The expression of glucose consumption-related genes such as UCP2 and GLUT4 increased significantly，while mRNA level of PDK2 and PDK4，as the negative regulator of glucose oxidation，increased significantly in the skeletal and cardiac muscle of HFD+BVT mice. In liver，11β-HSD1 inhibitor significantly reduced the key genes expression of lipid synthesis，including SREBP and FAS. Interestingly，11β-HSD1 inhibitor also significantly inhibited the critical glucose reabsorption genes expression of SGLT1 and SGLT2 in kidney. On the other hand，there was significant inhibition of the typical inflammatory gene，such as TNF-α，MCP1，IL-6 and IL-5，both in skeletal and cardiac muscles. Conclusion：BVT.2733 had a remarkable effect on the expressions of specific genes related to metabolism and inflammation in skeletal muscular，cardiac，hepatic，renal and splenic tissues in obese mice.