The application value of COPD assessment test（CAT）and monitoring oxygen saturation in management of patients with chronic obstructive pulmonary disease
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摘要:
目的：探讨慢性阻塞性肺病（chronic obstructive pulmonary disease，COPD）评估测试（COPD assessment test，CAT）联合指脉氧监测在COPD患者管理中的应用价值。方法：分析57例COPD患者CAT评分、日常步行运动指脉氧、COPD指脉氧评估测试（COPD assessment test and SpO2，CATS）与肺功能之间的相关性，比较少症状组（CAT＜10分）、多症状组（CAT≥10分）患者指脉氧的差异。结果：CAT总分、症状相关评分、生活状态评分均与第1秒用力呼气的容积占预计值的百分比（FEV1%pred）呈负相关；静息指脉氧（SpO2B）、最低指脉氧（SpO2L）与FEV1%pred呈正相关，ΔSpO2与FEV1%pred呈负相关；CATS与FEV1%pred呈负相关，与生活状态评分呈正相关。其中，少症状组生活状态评分及SpO2B与FEV1%pred有相关性；多症状组CAT总分、生活状态评分、ΔSpO2与FEV1%pred呈负相关，SpO2L与FEV1%pred呈正相关。多症状组的SpO2B与SpO2L均低于少症状组，而ΔSpO2高于少症状组。结论：指脉氧监测有助于发现COPD急性加重期患者；CAT评分中的生活状态评分较症状相关评分与COPD患者肺功能关系更为密切；指脉氧监测与CAT评分联合即CATS有助于COPD的管理和精准治疗。
Abstract:
Objective：To investigate the application value of chronic obstructive pulmonary disease（COPD）assessment test（CAT）and monitoring pulse oxygen saturation（SpO2）in management of patients with COPD. Methods：The correlations of CAT，SpO2 during walking，CAT and SpO2（CATS）with pulmonary function were analyzed respectively. The difference of SpO2 was also analyzed between the two groups which were defined as CAT＜10 and CAT≥10. Results：CAT total score，respiratory CAT score，non-respiratory CAT score，SpO2B，SpO2L，ΔSpO2，CATS were all associated with FEV1（forced expiratory volume in 1 second）% predicted. CATS was also associated with non-respiratory CAT score. In CAT＜10 group，non-respiratory CAT score and SpO2B were associated with FEV1%pred. In CAT ≥10 group，CAT total score，non-respiratory CAT score，SpO2L and ΔSpO2 were associated with FEV1%pred. The SpO2B and SpO2L in CAT≥10 group were higher，and ΔSpO2 was lower than those in CAT＜10 group. Conclusion：Monitoring oxygen saturation may be helpful in diagnosis of acute exacerbation of COPD patients. Non-respiratory CAT score contributes more to CAT total score than respiratory CAT score. CATS，the combination of oxygen saturation and CAT，will improve the management of COPD and precision medicine treatment.
