Objective：This study aims to explore the prognostic value of C-reactive protein-to-albumin（CRP/ALB）ratio（CAR）in diagnosed diffuse large B-cell lymphoma（DLBCL）. Methods：The clinical data of newly diagnosed DLBCL patients diagnosed in the First Affiliated Hospital of Nanjing Medical University between December 2009 and December 2018 were analyzed retrospectively. Progression-free survival （PFS） and overall survival （OS） were calculated by Kaplan-Meier method. Cox proportional hazards models were used for the univariate and multivariate analysis. Results：A total 314 newly diagnosed DLBCL patients were enrolled in the study. Up to June 2019，median follow up time was 50 months，and the median PFS and OS were unreached. Patients with higher CAR had shorter PFS and OS（P < 0.001）. The multivariate analysis strongly demonstrates that CAR is an independent predictor for both PFS（P=0.006）and OS（P=0.009）. Furthermore，the predictive and discriminatory capacity of National Comprehensive Cancer Network International Prognostic Index（NCCN-IPI）together with CAR level was superior to alone for PFS（P=0.010）and OS（P=0.002）. Conclusion：CAR is a simple and easily accessible parameter，which may be a good candidate for predicting prognosis of DLBCL.