Clinical medical research is the core driving force of medical development. In the context of big data，the China government provided institutional guarantee and resource support for the clinical medical research through top-level design. The rapid development of multi-omics and information technology has provided valuable resource accumulation，helped the continuous innovation，and catalyzed the continuous change for China’s clinical medical research. China’s clinical medical research is facing new opportunities. However，China’s biomedical big data still has challenges such as fragmentation of storage and lack of data exchange mechanisms. It is urgent to establish a government-led data sharing mechanism and seek a cooperative research model. In the new era，real-world research relying on big data will gradually become an important source of evidence for clinical intervention. We must strengthen the accumulation of clinical data as well as biological sample，innovate research methods，break the traditional thinking mode，and meet new opportunities and challenge.