Objective：This paper is aimed to analyze the effect of flexible plantar pressure feedback training system on rehabilitation intervention of patients with early ischemic stroke by functional magnetic resonance imaging（fMRI），and to summarize the characteristics and mechanism of brain function remodeling. Methods：Twelve stroke patients were randomly divided into two groups with 30 days walking training，the experimental group for the combination of flexible plantar pressure feedback system training，the control group for traditional training. Lateralization index（LI）was used to analyze the results of brain activation，and the correlation was analyzed with motor function assessment. Results：The locomotion function of the experimental group changed significantly compared with that of the control group（P < 0.001）. Meanwhile，there was a significant correlation between the training of flexible plantar pressure feedback training system and the recovery of locomotion function. In hemiplegic side movement，the LI value of hemiplegic side was significantly correlated with the training of flexible plantar pressure feedback system（r=0.884，P < 0.001）. The similar results happened in contralateral movement. The LI value of contralateral side was also significantly correlated with the training of flexible plantar pressure feedback system（r=0.892，P < 0.001）. Especially after flexible plantar pressure feedback system training，there was a significant correlation between the LI values of ROI in both hemispheres of stroke patients’ brain（r=0.974，P < 0.001）. Conclusion：The flexible plantar pressure feedback training system can significantly improve the motor function of lower limbs and fundamentally accelerate the rehabilitation process of stroke patients.