Objective：This study aims to evaluate the clinical efficacy about triamcinolone acetonide oral ointment on minor recurrent aphthous ulcer（RAU）. Methods：Patients were selected from the Department of Oral Mucosal Disease，the Affiliated Stomatological Hospital of Nanjing Medical University from July 2018 to March 2019，and they were randomly divided into 3 groups . Group A was given with triamcinolone acetonide oral ointment and Kouyanqing granule； group B was treated with recombinant bovine basic fibroblast growth factor and Kouyanqing granule，group C was treated with Guilin watermelon frost spray and Kouyanqing granule. The scores of the visual analog scale（VAS） and the area and exudation as well as hyperemia of the target ulcer of patients were recorded at the first visit，the 3rd，5th and 7th day of follow-up respectively. At the same time，the ulcer healing time and analgesic time were also recorded. Results：The average healing time and the analgesic time of group A were significantly shorter than that in other two groups（P < 0.05）. The average laxation score of VAS about the target ulcers on the 3rd and 7 th day in group A was significantly higher than that in other two groups（P < 0.05）. On the third day，the reduced area of target ulcer of group A was significantly better than that of other two groups（P < 0.05）. At the same time，the exudation score and hyperemia score of group A were significantly different from the other two groups（P < 0.05） only on the fifth day. Conclusion：Triamcinolone acetonide oral ointment has a significant effect on promoting ulcer healing and reducing pain of patients suffering in the treatment of minor recurrent aphthous ulcer.