Objective：To quantitatively analyze the clinical application value of electronystagmography in early-stage Alzheimer’s disease（AD）by combining cerebrospinal fluid markers and cognitive neuropsychological scale. Methods：The subjects were divided into three groups：individuals with mild cognitive impairment（aMCI group），mild AD（AD group）and normal controls，with 20 cases in each group. After completing the evaluation of the cognitive scale，the three groups of patients were examined by electronystagmography and cerebrospinal fluid markers，and the results were statistically analyzed. Results：①In the saccade test，there was a significant difference in the number of accuracy abnormalities between the AD group and the other two groups（P < 0.05），and a significant difference in the latency between the control group and the other two groups（P < 0.001）. ②MOCA，SDMT，CDT，MMSE，and ADL scores were negatively correlated with saccade latency，and the attachment test scores were positively correlated with saccade latency. ③There was a significant negative correlation between the level of Aβ1-42 and the latency of saccade. Conclusion：There is eye movement damage in early-stage AD patients，which is mainly manifested by decreased accuracy and prolonged latency. Electronystagmography is helpful for early AD screening.