Analysis of electronystagmography in patients with early⁃stage Alzheimer’s disease
Author:
Affiliation:
Fund Project:
摘要
|
图/表
|
访问统计
|
参考文献
|
相似文献
|
引证文献
|
资源附件
|
文章评论
摘要:
目的:结合脑脊液标志物及认知神经心理量表,定量分析眼震电图在早期阿尔茨海默病筛查和治疗中的应用价值。方法:选取遗忘型轻度认知功能障碍(amnesia mild cognitive impairment,aMCI组)、轻度阿尔茨海默病(AD组)及健康人(对照组)各20例,3组病例在完成认知量表评估后进行眼震电图检查及脑脊液标志物检测,对所得结果进行统计分析。结果:①扫视试验中,3组的准确度异常发生率存在统计学差异,其中AD组准确度异常的发生率高于对照组及aMCI组(P<0.05);3组的潜伏期具有统计学差异,其中aMCI组及AD组的潜伏期均高于对照组,差异有统计学意义(P<0.001)。②蒙特利尔认知评估量表(Montreal cognitive assessment,MOCA)、符号数字模式测验(symbol digit modalities test,SDMT)、画钟测试(clock drawing test,CDT)、简易智力状态检查(mini-mental state examination,MMSE)、日常生活能力量表(activity of daily living scale,ADL)得分与扫视潜伏期存在负相关关系,连线测验与扫视潜伏期具有正相关关系。③脑脊液标志物中,Aβ1-42水平与扫视潜伏期之间存在负相关关系(r=-0.662,P<0.001)。结论:早期AD患者存在眼动损害,主要表现为准确度下降和潜伏期延长。视频眼震电图检测有助于早期AD的筛查。
Abstract:
Objective:To quantitatively analyze the clinical application value of electronystagmography in early-stage Alzheimer’s disease(AD)by combining cerebrospinal fluid markers and cognitive neuropsychological scale. Methods:The subjects were divided into three groups:individuals with mild cognitive impairment(aMCI group),mild AD(AD group)and normal controls,with 20 cases in each group. After completing the evaluation of the cognitive scale,the three groups of patients were examined by electronystagmography and cerebrospinal fluid markers,and the results were statistically analyzed. Results:①In the saccade test,there was a significant difference in the number of accuracy abnormalities between the AD group and the other two groups(P < 0.05),and a significant difference in the latency between the control group and the other two groups(P < 0.001). ②MOCA,SDMT,CDT,MMSE,and ADL scores were negatively correlated with saccade latency,and the attachment test scores were positively correlated with saccade latency. ③There was a significant negative correlation between the level of Aβ1-42 and the latency of saccade. Conclusion:There is eye movement damage in early-stage AD patients,which is mainly manifested by decreased accuracy and prolonged latency. Electronystagmography is helpful for early AD screening.