Certain chemotherapeutic drugs can elicit immunogenic cell death while inducing apoptosis of tumor cells. Generally，they have better therapeutic effects. This procedure is mainly characterized by up-regulation of certain characteristic protein molecules，such as calreticulin（CRT），high mobility group box 1（HMGB1），on the surface of apoptotic cells. These proteins can induce immature dendritic cells to maturation and present tumor antigens to cytotoxic T cells. Eventually，activated tumor-specific cytotoxic T cells kill tumor cells and ultimately achieve better therapeutic effects. The study of tumor immunogenic cell death will provide new methods and approaches for tumor treatment，and provide new ideas for tumor immunity study.