血管紧张素转化酶2/血管紧张素(1⁃7)信号轴与新型冠状病毒肺炎的关系探究
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国家自然科学基金面上项目(81470538)


Exploration of relationship between angiotensin⁃converting enzyme 2/ angiotensin(1⁃7) signal axis and COVID⁃19
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    摘要:

    血管紧张素转换酶 2(angiotensin-converting enzyme 2,ACE2)是人体肾素-血管紧张素系统(renin-angiotensin system,RAS)的一个重要成员,其生理作用主要是催化血管紧张素(angiotensin,Ang)Ⅱ转换为Ang-(1-7)。新型冠状病毒的暴发和快速的传播能力,使其成为全世界共同关注的重大突发公共卫生事件。新型冠状病毒通过与人体黏膜上皮细胞膜表面的ACE2结合入侵细胞,并且大量复制,产生肺炎。其传染性强,目前无确切有效的治疗方式。高血压是新型冠状病毒肺炎最常见的合并症。新型冠状病毒肺炎患者体内ACE/Ang Ⅱ/AT1R轴和ACE2/Ang-(1-7)/Mas轴失衡,本课题组既往对Ang-(1-7)的系列研究和其他实验室的研究结果显示,Ang-(1-7)具有保护心肺功能、舒张血管、降低血压、上调ACE2表达的作用。外源性给予Ang-(1-7)不仅可以缓解和扭转人体自身的RAS失衡,还可以对肺部、心血管等系统起到支持和保护作用。因此Ang-(1-7)具有治疗或缓解新型冠状病毒肺炎合并高血压的潜在可能。

    Abstract:

    Angiotensin converting enzyme 2(ACE2) is an important member of renin-angiotensin system(RAS) in human body,and its physiological function is mainly to catalyze the conversion of angiotensin (Ang)Ⅱ to Ang-(1-7). The massive outbreak of the novel coronavirus and its rapid infectious capacity have made it a major public health emergency of global concern. According to statistics,a quarter of the patients have complications,and hypertension is the most common one. The novel coronavirus invades cells by binding to ACE2 on the cell membrane of the human mucosal epithelium and replicates in large numbers inside of cells to produce pneumonia. Its infectivity is strong,and at present,there are still not the definite effective treatment way. In patients with COVID-19,the ACE/Ang Ⅱ/AT1R axis and ACE2/Ang-(1-7)/Mas axis are out of balance. According to our previous study results and the findings from other laboratories,we find that Ang-(1-7) protects cardiopulmonary function,relaxes blood vessels,decreases blood pressure and up-regulates ACE2 expression. Exogenous administration of Ang-(1-7) might not only alleviate and reverse the imbalance of RAS inside of the human body,but also play a supporting and protective role in the pulmonary and cardiovascular systems. Therefore,we speculate that Ang-(1-7) has the potential to treat or relieve the COVID-19 in patients with hypertension.

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许 驭,韩 莹.血管紧张素转化酶2/血管紧张素(1⁃7)信号轴与新型冠状病毒肺炎的关系探究[J].南京医科大学学报(自然科学版),2020,(10):1414-1419

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  • 收稿日期:2020-06-19
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  • 在线发布日期: 2020-11-10
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