Objective：Effects of statin for reducing mortality is controversial in individuals aged 75 years or older. We undertook this study to investigate whether there is an association between statin therapy and the risk of mortality in patients over the 75 years with type 2 diabetes mellitus （T2DM）. Methods：The present study was conducted using the data taken from the Staged Diabetes Targeting Management Study（SDTM），which was started since 2010. A total of 4 285 diabetic patients were enrolled in the SDTM study until September 2017. There were 172 T2DM patients dead for the final analysis. There were 165 age and gender-matched individuals who remained survival during the median follow-up of 7.4 years selected as controls. Details on personal information，history of disease and use of medications were obtained through interviews by the nurses. Results：Logistic regression results showed that there was no statistically significant association between statin and mortality in the total population. After adjusting for age and gender，statins did not reduce the overall risk of death in patients with type 2 diabetes（OR 0.61，95%CI 0.36~1.01）. Further stratified analysis was carried out according to gender，CHD disease history and LDL-c levels. Statin use was associated with a reduced risk of death in female. Odds ratio and 95% confidence interval was 0.538 and（0.256~1.131），respectively. After further adjustment for age，gender and all potential confounders，OR（95%CI） was 0.36（0.15~0.85），P < 0.05. Conclusion：Statin use did not significantly reduce the risk of death in old people with T2DM. However，statin use may reduce the risk of death in women because of hormonal effects.