Correlation between metabolic parameters of 18F ⁃ FDG PET and related metabolic
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摘要:
目的：探讨肺小细胞癌中18F-FDG PET/CT的各项代谢参数与神经内分泌标志物（Syn、CgA、CD56）、TTF-1、Ki-67表达的相关性及其预后价值。方法：回顾性分析南京医科大学第一附属医院2009年1月—2017年5月经病理证实的96例肺小细胞癌的免疫组化及18F-FDG PET/CT显像资料。结果：96例肺小细胞癌的原发灶最大标准摄取值（primary lesion maximum standardized uptake value，PSUVmax）、总病灶代谢体积（whole body lesion metabolic tumor volume，WBMTV）、总病灶糖酵解总量（whole body lesion glycolysis，WBTLG）分别为10.30（1.20~42.90）、108.44（0.41~710.40）cm3、585.73（1.30~10 668.50），TTF-1阴性组与阳性组的PSUVmax、WBMTV、WBTLG差异有统计学意义（Z=-3.063、-2.235、-2.538，P=0.002、0.025、0.011）；PSUVmax值与Ki-67的表达呈正相关（r=0.620，P＜0.05）；单因素生存分析表明TTF-1、CD56、WBMTV、WBTLG与总生存期（overall survival，OS）相关（HR值：0.477、0.090、2.862、2.795，P均＜0.05）；多因素生存分析显示CD56及WBMTV是OS的独立预后因素（HR值：0.092、1.007，P均＜0.05）。结论：肺小细胞癌中18F-FDG PET/CT显像的各项代谢参数与TTF-1、Ki-67的表达具有较好的相关性，而与神经内分泌标志物无明显相关性；CD56及WBMTV是OS的独立预后因素。
Abstract:
Objective：This study aims to investigate the correlation between the metabolic parameters of 18F-FDG PET/CT and the expression of neuroendocrine markers（Syn，CgA，CD56），TTF-1 and Ki-67，and the value of prognosis in small cell lung cancer（SCLC）. Methods：The immunohistochemical data and 18F-FDG PET/CT data of 96 SCLC cases confirmed by pathology were retrospectively analyzed，the cases collected from January 2009 to May 2017 in the First Affiliated Hospital of Nanjing Medical University. Results：The median of primary lesion maximum standardized uptake value（PSUVmax），whole body lesion metabolic tumor volume（WBMTV）and whole body lesion glycolysis（WBTLG）in 96 SCLC patients were 10.30（1.20~42.90）、108.44（0.41~710.40）cm3、585.73（1.30~10 668.50）；the values of PSUVmax，WBMTV and WBTLG had statistically significant differences between the negative and positive groups of TTF-1（Z=-3.063，-2.235，-2.538，P=0.002，0.025，0.011）. The Spearman correlation analysis shows that there was a positive correlation between PSUVmax and Ki-67 expression（r=0.620，P < 0.001）. Kaplan-Meier single factor analysis shows the expression of TTF-1 and CD56，WBMTV，WBTLG was significantly correlated with overall survival（HR：0.477，0.090，2.862，2.795，all P < 0.05）. Multivariate survival analysis showed that CD56 and WBMTV were independent prognostic factors of overall survival（OS）. Conclusion：The metabolic parameters of 18F-FDG PET/CT in SCLC had a good correlation with the expressions of TTF-1 and Ki-67，and no correlation with neuroendocrine markers. CD56 and WBMTV were the independent prognostic factors of OS.
