Objective：To analyze prognostic values of systemic inflammation-related indicators in preoperative peripheral blood of breast cancer patients. Methods：Preoperative inflammatory indexes，such as neutrophil-to-lymphocyte ratio（NLR），platelet-to-lymphocyte ratio（PLR），lymphocyte-to-monocyte ratio（LMR） and systemic immune-inflammation index（SII），were obtained from 380 breast cancer patients who complied with the selection criteria. PD-L1 expressions were detected by immunohistochemistry methods in tumor tissues of 36 triple negative breast cancer（TNBC） patients. The survival analysis was performed based on the rate of breast cancer-related death. Results：Levels of NLR and SII were related to maximum tumor diameter and clinical stage of breast cancer patients，while the PLR and LMR had no significant correlations with clinicopathological features. Univariate and multivariate analysis of survival showed that patients with high SII levels had shorter breast cancer specific survival. Meanwhile，levels of SII were probably correlated with PD-L1 expressions in TNBC patients. Conclusion：Preoperative SII levels could be associated with tumor staging and prognosis in breast cancer patients. There may be a correlation between positive PD-L1 expressions and low SII levels in the TNBC subgroup. Systemic inflammation-related indicators of preoperative peripheral blood may provide further choices for disease surveillance of breast cancer patients.