超长促排卵方案中基础LH水平对排卵正常患者IVF/ICSI治疗结局的影响
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常州市应用基础研究计划(CJ20179049)


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    摘要:

    目的:探讨超长促排卵方案中基础黄体生成素(basic luteinizing hormone,BLH)水平对排卵正常患者体外受精/卵胞浆内单精子注射(in vitro fertilization or intracytoplasmic sperm injection,IVF/ICSI)治疗结局的影响。方法:回顾性分析本中心2018—2019年就诊306例采用超长促排卵方案的排卵正常患者,按BLH水平不同分为低BLH组(BLH<5 U/L)158例和高BLH组(BLH≥5 U/L)148例。分别比较两组促性腺激素(gonadotrophic hormone,Gn)用量、平均Gn天数、扳机日血清激素水平、获卵数、优胚数、临床妊娠率等。结果:Gn用量、Gn天数、优势卵泡数、获卵数、成熟卵子数、正常受精数、优质胚胎数均无明显差异(P>0.05);获卵率、正常受精率、囊胚形成率两组也无统计学差异(P>0.05);但是高BLH组优质胚胎率明显高于低BLH组(P<0.001)。新鲜胚胎移植结果显示,低BLH组和高BLH组的临床妊娠率无统计学差异(65.3% vs. 64.8%,P>0.05);低BLH组的早期流产率(15.6%)明显高于高BLH组(4.4%),差异有统计学意义(P<0.05)。结论:超长促排卵方案中BLH水平对排卵正常患者IVF/ICSI治疗结局有一定影响,BLH水平偏高者更适合此方案。

    Abstract:

    Objective:To explore the effects of the basic luteinizing hormone(BLH) level in the super-long protocol on the outcome of IVF/ICSI treatment for patient with normal ovulation. Methods:The clinical data of 306 infertility women undergoning IVF/ICSI and stimulated by super-long protocols in our center from 2018 to 2019 were collected and retrospectively analyzed. According to the level of BLH,they were divided into low BLH group(BLH<5 U/L,158 cases)and high BLH group(BLH≥5 U/L,148 cases)respectively. The dosage of Gn,the average days of Gn,the serum hormone level on hCG day,the number of oocytes obtained,the number of high-quality embryos and the clinical pregnancy rate were compared between the two groups. Results:There was no significant difference of Gn dosage,Gn days,number of dominant follicles,number of oocytes obtained,number of MII oocytes,number of normal fertilization and number of high-quality embryos(P > 0.05);there was no significant difference of the rate of oocyte obtained,normal fertilization rate and blastocyst formation rate between the two groups(P > 0.05);but the rate of high-quality embryos in low BLH group was significantly higher than that in low BLH group(P < 0.001). The results of fresh embryo transfer showed that the clinical pregnancy rate was no statistical difference(65.3% vs. 64.8%,P > 0.05);but the early abortion rate of low BLH group(15.6%)was significantly higher than that of low BLH group(4.4%)(P < 0.05). Conclusion:The BLH of the patients with normal ovulation who was treated super-long protocol has a certain impact on the outcome of IVF/ICSI treatment,and the patients with high LH level is more suitable for this protocol.

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于春梅,王宇峰,戴秀亮,夏西洋,高亭亭,陈 莉.超长促排卵方案中基础LH水平对排卵正常患者IVF/ICSI治疗结局的影响[J].南京医科大学学报(自然科学版),2021,(1):88-91

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  • 收稿日期:2020-01-13
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  • 在线发布日期: 2021-02-04
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