CD109在口腔鳞状细胞癌中的表达及其临床意义
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无锡市卫健委科研项目(MS201909);太湖高层次人才(双百中青年医疗卫生拔尖人才)(BJ2020056)


Expression and clinical significance of CD109 in oral squamous cell carcinoma
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    摘要:

    目的:研究白细胞分化抗原109(cluster of differentiation 109,CD109)在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达并探讨其与患者临床特征及预后的关系。方法:采用实时定量PCR和免疫组织化学法检测OSCC组织中CD109 mRNA和蛋白的表达;结合临床病理资料分析CD109表达与临床特征及患者预后的关系。结果:在OSCC组织中,CD109的mRNA和蛋白表达水平明显高于癌旁组织(P<0.05);CD109表达与淋巴结转移(P=0.019)、远处转移(P=0.007)和美国癌症联合委员会癌症分期(P=0.031)相关;多因素分析证实CD109表达水平是OSCC患者的独立预后因素(P<0.001);与CD109低或无表达的OSCC患者相比,CD109高表达的OSCC患者总生存期更短(P=0.004)。结论:CD109是影响患者预后的独立危险因素,可能成为判断OSCC预后的肿瘤标志物。

    Abstract:

    Objective:This study aims to investigate the expression of CD109 in oral squamous cell carcinoma(OSCC)and its influence on clinical characteristics and prognosis. Methods:The expression of CD109 mRNA and protein in OSCC tissues were detected by real-time quantitative PCR and immunohistochemistry respectively. The relationships between CD109 expression and clinical characteristics and prognosis were analyzed according to clinicopathological data. Results:The mRNA and protein expression levels of CD109 in OSCC tissues were significantly higher than those in paracancerous oral tissues. CD109 expression was associated with lymph node metastasis(P=0.019),distant metastasis(P=0.007)and cancer stage according to American Joint Committee(P=0.031). Multivariate analysis confirmed that CD109 expression was an independent prognostic factor for OSCC patients(P < 0.001).OSCC patients with high CD109 expression had a poor overall survival compared with patients with low or none CD109 expression(P=0.004). Conclusion:CD109 is an independent risk factor affecting the prognosis of OSCC patients,and may be an important marker to predict the prognosis of OSCC.

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侯德强,白 宁,魏子程,程 洋,刘彦魁,汤根兄. CD109在口腔鳞状细胞癌中的表达及其临床意义[J].南京医科大学学报(自然科学版),2021,(3):339-343

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  • 收稿日期:2020-09-03
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  • 在线发布日期: 2021-04-01
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