Expression and clinical significance of CD109 in oral squamous cell carcinoma
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摘要:
目的：研究白细胞分化抗原109（cluster of differentiation 109，CD109）在口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）中的表达并探讨其与患者临床特征及预后的关系。方法：采用实时定量PCR和免疫组织化学法检测OSCC组织中CD109 mRNA和蛋白的表达；结合临床病理资料分析CD109表达与临床特征及患者预后的关系。结果：在OSCC组织中，CD109的mRNA和蛋白表达水平明显高于癌旁组织（P＜0.05）；CD109表达与淋巴结转移（P=0.019）、远处转移（P=0.007）和美国癌症联合委员会癌症分期（P=0.031）相关；多因素分析证实CD109表达水平是OSCC患者的独立预后因素（P＜0.001）；与CD109低或无表达的OSCC患者相比，CD109高表达的OSCC患者总生存期更短（P=0.004）。结论：CD109是影响患者预后的独立危险因素，可能成为判断OSCC预后的肿瘤标志物。
Abstract:
Objective：This study aims to investigate the expression of CD109 in oral squamous cell carcinoma（OSCC）and its influence on clinical characteristics and prognosis. Methods：The expression of CD109 mRNA and protein in OSCC tissues were detected by real-time quantitative PCR and immunohistochemistry respectively. The relationships between CD109 expression and clinical characteristics and prognosis were analyzed according to clinicopathological data. Results：The mRNA and protein expression levels of CD109 in OSCC tissues were significantly higher than those in paracancerous oral tissues. CD109 expression was associated with lymph node metastasis（P=0.019），distant metastasis（P=0.007）and cancer stage according to American Joint Committee（P=0.031）. Multivariate analysis confirmed that CD109 expression was an independent prognostic factor for OSCC patients（P < 0.001）.OSCC patients with high CD109 expression had a poor overall survival compared with patients with low or none CD109 expression（P=0.004）. Conclusion：CD109 is an independent risk factor affecting the prognosis of OSCC patients，and may be an important marker to predict the prognosis of OSCC.
