2011年与2017年南京市25岁以上人群归因于高胆固醇的疾病负担研究
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南京市医学科技发展项目(ZKX18049,YKK17199);南京市医学科技发展资金资助(QRX17199)


The burden of diseases from high total cholesterol among population in Nanjing between 2011 and 2017
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    目的:评估2011年与2017年南京市居民由于高胆固醇血症造成的疾病负担。方法:使用2011年及2017年南京市慢性病及其危险因素监测获得的血清总胆固醇(total cholesterol,TC)水平,计算高胆固醇的人群归因分值,进而利用死因登记资料和人口统计数据,评估高胆固醇血症造成的疾病负担。结果:2011年,南京市≥25岁人群血清TC水平为(4.57±1.86)mmol/L,男性(4.58±2.16)mmol/L,女性(4.55±1.58)mmol/L。2017年TC水平为(4.66±1.10)mmol/L,女性[(4.71±1.11)mmol/L]高于男性[(4.61±1.09)mmol/L]。2017年总体及女性的血清TC水平均高于2011年。2011年南京市人群全部死亡中,4.77%由高胆固醇造成,2017年有5.78%归因于高胆固醇,较2011年增长了21.17%。2011年南京人群高胆固醇归因标化死亡率为36.24/10万,2017年下降至30.08/10万,下降了17.00%,其中男性下降21.82%,女性下降11.29%。与2011年(631.07/10万)相比,2017年高胆固醇造成的标化过早死亡损失寿命年率(495.35/10万)下降了21.51%。2011年高胆固醇导致南京市人群期望寿命损失0.45岁,女性(0.49岁)高于男性(0.41岁)。2017年导致的期望寿命损失为0.66岁,女性(0.78岁)高于男性(0.54岁)。结论:南京市高胆固醇血症造成的疾病负担较重,2011年至2017年高胆固醇造成的死亡和期望寿命损失呈上升趋势。

    Abstract:

    Objective:This study aims to estimate the burden of diseases from high total cholesterol(TC)among population in Nanjing between 2011 and 2017. Methods:Population attributable fraction(PAF) of high TC were calculated by using data related to TC levels from chronic disease risk factor surveillance in Nanjing,2011 and 2017. By using the PAFs,data related to death and demographics of people in Nanjing were used to estimate the burden of diseases from high TC. Results:The level of TC in Nanjing population aged 25 and above was(4.57±1.86)mmol/L in 2011,(4.58±2.16)mmol/L for males and(4.55±1.58)mmol/L for females respectively,while appeared as (4.66±1.10)mmol/L in 2017,higher in females (4.71±1.11)mmol/L than that in males (4.61±1.09)mmol/L. In 2017,the level of TC was higher than that in 2011 among total population and women. As total of 4.77% of all deaths were attributed to high TC,while appeared as 5.78% in 2017 by increased of 21.17%. The mortality rate attributed to high TC in Nanjing population was 36.24/100 000 in 2011,which decreased to 30.08/100 000 in 2017,with a decrease of 17.00% in total,21.82% in males and 11.29% in females respectively. Compared with 2011(631.07/100 000),the rate of years of life lost(YLL) due to high TC in 2017(495.35/100 000) decreased by 21.51%. The loss of life expectancy caused by high TC in 2011 for Nanjing population was 0.45 years,higher in females(0.49 years)than that in males(0.41 years),and the loss of life expectancy in 2017 was 0.66 years,higher in females(0.78 years) than in males(0.54 years). Conclusion:High TC is a major risk factor for the burden of diseases and death. Deaths and loss of life expectancy caused by high TC increased from 2011 to 2017 in Nanjing.

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叶 青,范周全,杨华凤,周海茸,戚圣香,陈旭鹏,周金意,洪 忻.2011年与2017年南京市25岁以上人群归因于高胆固醇的疾病负担研究[J].南京医科大学学报(自然科学版),2021,(3):428-433

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  • 收稿日期:2020-04-23
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  • 在线发布日期: 2021-04-01
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