Objective：To study correlation of cancer-associated fibroblasts（CAFs），CD4+，CD8+ T lymphocyte with developments and lymph node metastasis of breast carcinoma. Methods：Immunohistochemistry method（S-P）was used to examine the expression of α-smooth muscle actin（α-SMA），CD4 and CD8 in breast invasive ductal carcinoma，and the relationships with the clinicopathological features of breast carcinoma were analyzed to explore the correlation between CAFs induced immunosuppression and the development and lymph node metastasis of breast carcinoma. Results：The positive rate of α-SMA was significantly higher in breast carcinoma than that in control. The expression rate of α-SMA was positively correlated to the tumor size，TNM stage and lymph nodal involvement（P＜0.05）. The expression of CD4 was negatively correlated to the grade and lymph nodal involvement（P＜0.05）. The expression of CD8 was positively correlated to the grade and lymph nodal involvement（P＜0.05）. The expression of α-SMA was positively correlated to the expression of CD8（P＜0.01），and it was negatively correlated to the expression of CD4（P＜0.01）. Conclusion：Abnormal CAFs and CD4+，CD8+ T lymphocytes promote the occurrence，development and lymphatic metastasis of breast cancer，and they provide reliable laboratory basis to evaluate the survival and prognosis of breast cancer patients.