Correlation of APOE gene polymorphism and advanced glycation end products with coronary heart disease in elderly patients
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摘要:
目的：对老年冠心病患者载脂蛋白E（apolipoprotein E，APOE）基因多态性与晚期糖基化终产物等相关危险因素进行分析。方法：在46例老年冠心病患者（冠心病组）和44例非冠心病患者（对照组）中观察APOE基因多态性的分布并用ELISA法测定血浆羧甲基赖氨酸（carboxy methyl lysine，CML）、可溶性晚期糖基化终末产物受体（soluble receptor for advanced glycation end products，sRAGE）的水平。结果：冠心病组APOEε4等位基因频率明显高于对照组（P＜0.05），冠心病组患者血浆CML、sRAGE水平高于对照组，但差异无统计学意义。冠心病组APOEε4携带者的血浆CML、sRAGE水平与对照组APOEε4携带者无显著差异。老年人冠心病危险因素分析得到APOEε4携带者患冠心病的风险是非携带者的3.511倍（P＜0.05），而CML、sRAGE水平与冠心病风险增加无显著相关性。结论：随着年龄增长，APOEε4等位基因仍然是老年冠心病患者的独立危险因素，而晚期糖基化终产物水平与老年人冠心病之间无显著相关性。
Abstract:
Objective：This study aims to analyze the risk factors related to apolipoprotein E（APOE）gene polymorphism and advanced glycation end products in elderly patients with coronary heart disease. Methods：The distribution of APOE gene polymorphism in 46 elderly patients with coronary heart disease and 44 non-coronary heart disease patients（control group）was observed，and the plasma levels of carboxy methyl lysine（CML）and soluble receptor for advanced glycation end products（sRAGE）were determined by ELISA. Results：The allele frequency of ApoE ε4 in coronary heart disease group was significantly higher than that of the control group（P < 0.05），and the level of plasma CML and sRAGE in coronary heart disease group was higher than that of the control group，with no statistically significant difference. The plasma CML and sRAGE levels of APOE ε4 carriers in the coronary heart disease group were not significantly different from those in the control group.The risk factors of coronary heart disease in elderly patients with APOE ε4 carriers were 3.511 times that of non-carriers（P < 0.05），but CMLand sRAGE levels were not significantly associated with an increased risk of coronary heart disease. Conclusion：With age，APOE ε4 allele remained an independent risk factor for coronary heart disease in elderly patients，and there was no significant correlation between advanced glycation end products level and coronary heart disease in elderly patients.
