NGAL在早发急性ST段抬高型心肌梗死患者预后评估中的应用价值
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

淮安市自然科学研究计划(HAB202025);南京医科大学附属淮安第一医院科研启动经费资助项目(YGRS202006)


The application value of neutrophil gelatinase⁃associated lipocalin in the prognosis assessment among patients with premature ST⁃segment elevation myocardial infarction
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:研究早发急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)的危险因素,探讨血浆中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)水平与早发STEMI的相关性及预后评估价值。方法:选取2017年1月—2018年12月确诊为早发STEMI的患者166例,同期行冠脉造影且血管管腔狭窄<50%的患者171例作为对照组。随访12个月,探讨早发STEMI患者发生主要不良心血管事件(major adverse cardiac events,MACE)的危险因素。行受试者工作特征(receiver operating characteristic,ROC)曲线分析,探讨NGAL预测患者发生MACE的最佳界值。结果:早发STEMI组的NGAL水平明显高于对照组,差异具有统计学意义(P < 0.05)。早发STEMI患者MACE组的NGAL水平明显高于无MACE组,差异具有统计学意义(P < 0.05)。Logistic回归结果显示,NGAL水平是早发STEMI患者发生MACE的独立危险因素(P < 0.05)。ROC曲线分析显示,NGAL预测患者发生MACE的曲线下面积为0.897(P < 0.05)。结论:早发STEMI患者的NGAL水平明显增高,且与MACE的发生密切相关,对评估早发STEMI患者的预后具有重要的临床应用价值。

    Abstract:

    Objective:To study the risk factors of patients with premature ST-segment elevation myocardial infarction(STEMI) and investigate the correlation between neutrophil gelatinase-associated lipocalin(NGAL) and premature STEMI and its clinical value in the prognosis assessment. Methods:Totally 166 patients diagnosed as premature STEMI from Jan 2017 to Dec 2018 were selected and followed up for 12 months,and 171 patients underwent coronary angiography during the same period with lumen stenosis <50% were selected as the control group. The risk factors of major adverse cardiac events(MACE) occurrence in premature STEMI patients were analyzed. Receiver operating characteristic(ROC) curve was used to find the optimal cutoff point for predicting the occurrence of MACE. Results:NGAL levels were significantly higher in premature STEMI group than those in control group(P < 0.05). NGAL levels were significantly higher in MACE group compared with non-MACE group(P < 0.05). Multivariate logistic regression analysis showed that NGAL was independently associated with MACE occurrence in premature STEMI patients(P < 0.05). ROC curve of NGAL in predicting the occurrence of MACE showed that the area under curve of NGAL were 0.897(P < 0.05). Conclusion:NGAL levels which were significantly elevated in premature STEMI patients are positively related with MACE occurrence. Thus NGAL can be used as a predictor of prognosis assessment in premature STEMI patients.

    参考文献
    相似文献
    引证文献
引用本文

张 鑫,张喜文,谷 阳. NGAL在早发急性ST段抬高型心肌梗死患者预后评估中的应用价值[J].南京医科大学学报(自然科学版),2021,(10):1453-1456

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2020-11-24
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2021-11-05
  • 出版日期:
通知关闭
郑重声明