ABVD化疗方案对霍奇金淋巴瘤患者睾丸18F⁃FDG代谢的影响
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The impact of ABVD chemotherapy regime on testicular 18F⁃FDG uptake in patients with Hodgkin’s lymphoma
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    目的:探讨ABVD(阿霉素、博来霉素、长春碱、氮烯咪胺,简称ABVD)方案化疗对霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)患者睾丸氟代脱氧葡萄糖(18F-FDG)代谢的影响。方法:回顾性分析34例(均行6个疗程的ABVD方案化疗)利用18F-FDG PET/CT进行疗效评估的HL患者资料。收集患者4次行18F-FDG PET/CT检查时(基线期及每2次疗程化疗行一次检查)的血糖、体重、注射剂量、注射时间、睾丸及纵隔血池的最大标准摄取值(SUVmax)。分析HL患者在4次18F-FDG PET/CT检查后睾丸18F-FDG代谢的变化情况。结果:34例HL患者4次18F-FDG PET/CT检查中仅睾丸SUVmax和体重的差异有统计学意义(P=0.017,P=0.001)。HL患者第2次PET/CT检查时的睾丸SUVmax较第1次减低了0.998,P=0.045;但第3、4次睾丸SUVmax与第1次无明显差异,并且后3次PET/CT检查时睾丸SUVmax未见明显变化(P>0.05)。患者在第1次PET/CT检查时(基线期)的睾丸SUVmax与纵隔血池SUVmax之间存在正相关(r=0.51,P=0.002),而睾丸SUVmax与年龄之间无相关性(P=0.646)。患者在后3次PET/CT检查时的体重均较第1次增高(P=0.009,0.004,0.016),但未发现后3次检查时患者的体重有明显变化(P>0.05)。结论:在接受ABVD方案化疗的HL患者中,睾丸的18F-FDG代谢程度在化疗过程中存在一过性减低,但后期可恢复;因此ABVD化疗方案可能对HL患者睾丸糖代谢的影响不大。

    Abstract:

    Objective:To investigate the impact of ABVD(adriamycin,bleomycin,vinblastine,dacarbazine) chemotherapy regime on the testicular 18F-fluorodeoxyglucose(FDG) uptake in patients with Hodgkin’s lymphoma(HL). Methods:Thirty-four patients at diagnosis monitored with 18F-FDG on positron emission tomography(PET)/computed tomography(CT) to assess treatment response for HL were selected for this retrospective analysis. The patients received ABVD chemotherapy regimen for six courses. The four 18F-FDG PET/CT examinations were performed at baseline and after every two courses of chemotherapy. Blood glucose,body weight,injection dose and injection time were collected,and the maximum standardized uptake value(SUVmax) of testis and mediastinal blood pool were measured. The changes of testicular 18F-FDG uptake in patients with HL after four 18F-FDG PET/CT examinations were analyzed. Results:There were statistical significance in testis SUVmax and weight(P=0.017,0.001) at four PET/CT examinations for 34 cases with HL. Compared with the testicular SUVmax at the first PET/CT examination,the testicular SUVmax at the second time decreased by 0.998,P=0.045. There were no significant differences in testicular SUVmax between the last two time points and the first time or over the course of chemotherapy(P>0.05). The testis SUVmax were found to be positively correlated with mediastinal blood pool SUVmax at the first PET/CT examination(baseline)(r=0.51,P=0.002),but not with age(P=0.646). The weight at last three PET/CT was higher than at the first time(P=0.009,0.004,0.016),but no changes were found during at last three PET/CT examinations(P > 0.05). Conclusion:For patients undergoing ABVD chemotherapy regime for Hodgkin’s lymphoma,the testicular 18F-FDG uptake decreased temporarily over the course of chemotherapy,but recovered in the later. Therefore,ABVD chemotherapy regime may have little effect on testicular glycometabolism of patients with Hodgkin’s lymphoma.

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李洋洋,丁其勇,李天女,唐立钧. ABVD化疗方案对霍奇金淋巴瘤患者睾丸18F⁃FDG代谢的影响[J].南京医科大学学报(自然科学版),2021,(10):1485-1489

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  • 收稿日期:2020-11-09
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  • 在线发布日期: 2021-11-05
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