基于AFQ技术的CAE患儿脑白质纤维完整性改变的研究
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国家自然科学基金面上项目(82071455);江苏省卫生计生委科研课题面上项目(H2018062);南京市科技局医疗卫生国际联合研发项目(201911044)


Study on the changes of white matter fiber integrity in children with CAE based on AFQ
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    摘要:

    目的:通过分析儿童失神癫痫(childhood absence epilepsy,CAE)患儿脑白质纤维完整性的改变,以探讨CAE患儿认知损害的可能靶点。方法:选取2011年11月—2020年11月在南京市儿童院或南京脑科医院就诊的29例CAE患儿[男11例,女18例,平均年龄(8.4±1.9)岁]和年龄、性别相匹配的24例健康儿童[男9例,女15例,平均年龄(7.9±1.4)岁]使用德国西门子3.0T MRI仪采集所有被试的DTI及T1数据,通过AFQ软件提取出脑内20条白质纤维束,提取出每条纤维束100个等分节点上的各向异性分数(fractional anisotropy,FA)值及平均扩散率(mean diffusivity,MD)值,定量比较其差异。统计方法采用独立样本t检验及多重比较校正。结果:CAE患儿在大部分纤维束节点中可出现FA值下降及MD值升高,其中在弓形束及钩状束的改变最为明显。结论:CAE患儿存在脑内白质纤维束完整性的改变,且以弓形束及钩状束损伤为著,提示CAE患儿认知损害的靶点可能在弓形束及钩状束。

    Abstract:

    Objective:This study aims to explore the possible targets of cognitive impairment in children with childhood absence epilepsy(CAE) by analyzing the changes of white matter fiber integrity in children with CAE. Methods:From November 2011 to November 2020,there were 29 children with CAE,11 males and 18 females,with an average age of 8.4±1.9 years,from Nanjing Children’s Hospital or Nanjing Brain Hospital;and 24 healthy children were matched in age and sex,9 males and 15 females,with an average age of 7.9±1.4 years old. The DTI and T1 data of all subjects were collected by Siemens 3.0T MRI. Twenty white matter fiber bundles were extracted by AFQ,and the fractional anisotropy(FA) and mean diffusivity(MD) values on 100 equal sub-nodes of each fiber bundle were extracted. The differences between CAE group and control group in each node were compared. The statistical methods were independent sample t-test and multiple comparison correction. Result:The FA decreased and MD increased in most fiber bundle nodes of CAE children,especially in uncinate and arcuate. Conclusion:The study suggests that there is a change of white matter fiber bundle integrity in children with CAE,especially in uncinate and arcuate. The damage of uncinate and arcuate is the main targets of cognitive impairment in CAE.

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余传勇,邱文超,孙锦涛,高 媛,王小姗.基于AFQ技术的CAE患儿脑白质纤维完整性改变的研究[J].南京医科大学学报(自然科学版),2021,(12):1767-1773

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  • 收稿日期:2021-05-23
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  • 在线发布日期: 2021-12-30
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