Autoimmune gastritis，induced by abnormal autoimmune reaction，has a complicated pathogenesis and unclarified etiologies. Recently，some new progresses have been made on the pathogenesis of autoimmune gastritis. This article briefly summarizes and describes the new advances of the pathogenesis observed in genetic susceptibility，immunemechanism，and Helicobacter pylori （Hp）infection. Autoimmune gastritis may be caused by multiple factors and genes. The discovery of genetic susceptibility, the change of immune regulation mechanism，HP infection and the lack of vitamin D bring new dawn to clarify the pathogenesis of autoimmune gastritis. Targeted therapy for Fas/FasL pathway，manipulation of Toll-like receptor signal and development of new therapies for cytokines are expected to inhibit inflammatory diseases. Eradication of HP and active supplementation of vitamin D can inhibit the occurrence and development of autoimmune gastritis.