铁死亡在颅脑外伤中的研究进展
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国家自然科学基金(81972153)


The role of ferroptosis in traumatic brain injury
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    摘要:

    颅脑外伤(traumatic brain injury,TBI)是由外力引起的大脑结构和生理功能破坏的损伤性疾病。它是全世界导致患者死亡和残疾的主要原因。颅脑外伤包括原发性和继发性损伤。铁含量的过度积累和铁死亡进程高度参与继发性脑损伤的病理生理过程。铁死亡是一种可调节的程序性细胞死亡,因为脑内铁积累增加导致脂质过氧化、活性氧(reactive oxygen species,ROS)产生、线粒体功能障碍和神经炎症反应,从而导致神经元的损伤。因此,减少铁的过度积累和抑制脂质过氧化等因素可能是一种有前途的治疗方法。铁螯合剂可以消除过量的铁,减轻部分颅脑外伤的临床症状。文章将重点讨论在颅脑外伤中的铁含量和铁死亡的机制,以拓宽对铁螯合剂治疗脑外伤的认识,为进一步的颅脑外伤治疗寻找新的研究方向。

    Abstract:

    Traumatic brain injury(TBI)is a structural and physiological disruption of brain function caused by external forces. It is the leading cause of death and disability worldwide. TBI includes both primary and secondary injuries. Excessive iron accumulation and ferroptosis are highly involved in the pathophysiological process of secondary brain injury. Ferroptosis is a form of regulatory cell death,characteristic as increased iron accumulation,lipid peroxidation,reactive oxygen species(ROS)production,mitochondrial dysfunction and neuroinflammatory responses,resulting in cellular and neuronal damage. For this reason,eliminating factors like excessive accumulation of iron and inhibiting lipid peroxidation may be a promising therapy approach. Iron chelators can be used to eliminate excess iron and to alleviate some of the clinical manifestations of TBI. In this review,it was focused on the mechanisms of iron and ferroptosis involved in the manifestations of TBI,broadening our understanding of the use of iron chelators for TBI,better seeking new research directions for further treatment of TBI.

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包钟元,季 晶.铁死亡在颅脑外伤中的研究进展[J].南京医科大学学报(自然科学版),2022,42(2):270-278

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  • 收稿日期:2021-09-27
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  • 在线发布日期: 2022-03-01
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