老年冠心病患者生存影响因素分析
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江苏省干部保健科研课题(BJ18017, BJ19016)


Analysis of factors influencing the survival of elderly patients with coronary heart disease
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    摘要:

    目的:分析老年冠心病患者生存的影响因素。方法:收集140例老年冠心病患者的相关资料,平均随访3.5年。探讨患者发生主要不良心脑血管事件(major adverse cardiac and cerebral events,MACCE)的影响因素,进一步分析各影响因素对MACCE的预测价值。结果:根据MACCE组与无MACCE组临床资料比较、Cox回归分析及Kaplan-Meier曲线分析结果,尿素氮(blood urea nitrogen,BUN)、总胆固醇(total cholesterol,TC)、左房内径(left atrial diameter,LAD)、心脏瓣膜钙化(cardiac valve calcification,CVC)是老年冠心病患者发生MACCE的相关影响因素。未发现1,25羟维生素D3水平与MACCE的发生相关。受试者工作特征(receiver operating characteristic,ROC)曲线显示,联合BUN、TC、LAD、CVC预测MACCE的价值最大。结论:BUN、TC、LAD、CVC是老年冠心病患者发生MACCE的重要影响因素,而未发现1,25羟维生素D3水平与MACCE的发生相关。

    Abstract:

    Objective:To observe and analyze the factors affecting the survival of elderly patients with coronary heart disease. Methods:Data of 140 elderly patients with coronary heart disease were collected and patients were followed up for an average of 3.5 years. The influencing factors of major adverse cardiac and cerebral events(MACCE) in patients were investigated,and the predictive value of each influencing factor for MACCE was further analyzed. Results:According to the comparison of clinical data between the MACCE group and the non-MACCE group,Cox regression analysis and Kaplan-Meier curve,blood urea nitrogen(BUN),total cholesterol (TC),left atrial diameter(LAD),and cardiac valve calcification(CVC) were associated with the development of MACCE in elderly patients with coronary heart disease. There was no correlation between 1,25 hydroxyvitamin D3 level and the occurrence of MACCE. According to the results of receiver operating characteristic(ROC) curve,the combination of BUN,TC,LAD and CVC had the greatest value in predicting MACCE. Conclusion:In this study,BUN,TC,LAD and CVC are found to be important influencing factors for the occurrence of MACCE in elderly patients with coronary heart disease,while there is no correlation between the level of 25 hydroxyvitamin D and the occurrence of MACCE.

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刘 欢,张晓宇,王向明,卢 妙,查志敏,闵笑颜,庞斯斯,李秋爽,郭 妍.老年冠心病患者生存影响因素分析[J].南京医科大学学报(自然科学版),2022,42(4):491-497

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  • 收稿日期:2021-08-15
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  • 在线发布日期: 2022-04-25
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